Monastir University, Tunisia.
Biochem Genet. 2010 Aug;48(7-8):647-57. doi: 10.1007/s10528-010-9346-z. Epub 2010 May 21.
GSTM1 and GSTT1 polymorphisms have been proposed in relationship with chronic obstructive pulmonary disease (COPD). We investigated the association between these polymorphisms and COPD (as well as its subtypes emphysema and chronic bronchitis) in 234 COPD patients and 182 healthy controls in the Tunisian population. Genotyping was performed using multiplex PCR. GSTM1-null genotype frequency was significantly higher in COPD patients than in controls (P = 0.02); however, multivariate analysis of cofounding variables showed no independent association with this genotype (P = 0.073). In contrast, the association of the GSTM1-null genotype with emphysema was significant, even after adjustment for risk factors (P = 0.011). There were no significant differences in GSTT1 genotypes between patients and controls. The GSTM1 null allele is likely not an independent risk factor for COPD but is related to emphysema, whereas the GSTT1 gene is not associated with the disease.
GSTM1 和 GSTT1 多态性与慢性阻塞性肺疾病（COPD）有关。我们在突尼斯人群中研究了这些多态性与 COPD（以及其亚型肺气肿和慢性支气管炎）之间的关系，共纳入了 234 例 COPD 患者和 182 例健康对照者。采用多重 PCR 进行基因分型。COPD 患者的 GSTM1 缺失基因型频率显著高于对照组（P = 0.02）；然而，对混杂变量的多变量分析显示，该基因型与 COPD 无独立相关性（P = 0.073）。相反，即使在调整了危险因素后，GSTM1 缺失基因型与肺气肿的相关性仍然显著（P = 0.011）。患者和对照组之间 GSTT1 基因型无显著差异。GSTM1 缺失等位基因可能不是 COPD 的独立危险因素，但与肺气肿有关，而 GSTT1 基因与该疾病无关。
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