Macedo Gustavo Guerino, DeRossi Rafael, Frazílio Fabrício Oliveira
Federal University of Viçosa, MG, Brazil.
Acta Cir Bras. 2010 Jun;25(3):298-303. doi: 10.1590/s0102-86502010000300014.
To evaluate the effects of bupivacaine 0.5 and 0.25% in intravenous regional anesthesia (IVRA) and brachial plexus block (BPB), respectively, on anesthesia, motor block and cardiovascular parameters in dogs.
Fourteen healthy adult dogs averaging 10 kilograms (kg) of body weight. Animals were randomly assigned to receive one of the two treatments IVRA (n=7) or BPB (n=7). All the animals were sedated with acepromazine (0.1 mg/kg intramuscular). To execute the BPB was used an electrical nerve stimulation. Anesthesia, motor block, sedation, cardiovascular and respiratory effects were measured as effect of the treatment.
BPA showed superior efficiency and duration of anesthesia (BPB - 456 +/- 94 minutes vs IVRA - 138 +/- 44) as well as motor block. There only physiologic parameter which change were the systolic pressure in BPB and respiratory rate for both treatments.
In dogs the 0.25 % hyperbaric bupivacaine in BPB produces a front limb anesthesia about three times more than the 0.5 % in IVRA, with ptosis of the limb blocked and little interference in the cardiovascular system but with decrease in respiratory rate.
分别评估0.5%和0.25%布比卡因在静脉区域麻醉（IVRA）和臂丛神经阻滞（BPB）中对犬麻醉、运动阻滞及心血管参数的影响。
14只平均体重10千克的健康成年犬。动物被随机分配接受IVRA（n = 7）或BPB（n = 7）两种治疗之一。所有动物均用乙酰丙嗪（0.1毫克/千克肌肉注射）镇静。采用电神经刺激进行BPB。测量麻醉、运动阻滞、镇静、心血管和呼吸效应作为治疗效果。
BPB显示出更高的麻醉效率和持续时间（BPB - 456 ± 94分钟 vs IVRA - 138 ± 44）以及运动阻滞。唯一有变化的生理参数是BPB中的收缩压以及两种治疗的呼吸频率。
在犬中，BPB中0.25%的高压布比卡因产生的前肢麻醉效果比IVRA中0.5%的布比卡因约高三倍，伴有阻滞肢体下垂，对心血管系统干扰小，但呼吸频率降低。
