Department of Biomedical Engineering, City College of New York, City University of New York, New York, NY 10031, USA.
IEEE Trans Biomed Eng. 2010 Sep;57(9):2107-14. doi: 10.1109/TBME.2010.2050064. Epub 2010 May 24.
We have studied the effect of cell geometry on propagation velocity of the cardiac impulse using a subcellular computer model of myocardium. Variation of cell size has only small effects on longitudinal and transverse conduction velocities, when the ratio of cell length/width is constant, for cell sizes (length x width) between (60 microm x 20 microm) and (120 microm x 40 microm). The results were not dependent on gap-junction conductance (range 0.25-1 microS), gap-junction distribution, or the specific tissue architecture. Longitudinal conduction velocity increased with the cell length/width ratio and transverse velocity decreased. The cell length/width ratio was a good estimator of the anisotropic ratio. In conclusion, cell length/width ratio is more important than cell size in determining conduction velocity.
我们使用心肌的亚细胞计算机模型研究了细胞几何形状对心脏冲动传播速度的影响。当细胞长度/宽度的比例恒定时，细胞大小（长度 x 宽度）在（60 微米 x 20 微米）和（120 微米 x 40 微米）之间变化时，对纵向和横向传导速度的影响很小。结果与缝隙连接电导（范围为 0.25-1 微西门子）、缝隙连接分布或特定组织结构无关。纵向传导速度随细胞长度/宽度的比值增加而增加，而横向速度则减小。细胞长度/宽度的比值是各向异性比值的良好估算值。总之，细胞长度/宽度的比值比细胞大小更能决定传导速度。
