可可波罗种子乙醇提取物对小鼠的中枢神经系统抑制活性

CNS Depressant Activity of Ethanol Extract of Sterculia guttata seeds in mice.

作者信息

Katade S R, Misar A V, Mujumdar A M, Phalgune U D, Wakharkar R D, Deshpande N R

机构信息

T. R. Ingle Research Laboratory, Department of Chemistry, Sir Parshurambhau College, Pune-411 030, India.

出版信息

Indian J Pharm Sci. 2009 Jul;71(4):445-7. doi: 10.4103/0250-474X.57297.

DOI:10.4103/0250-474X.57297

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2865820/

Abstract

Shade dried, powdered seeds of Sterculia guttata were extracted using a Soxhlet extractor with ethanol. Ethanol was removed under reduced pressure and dried to obtained crude extract. This extract was evaluated for its effect on behavioral changes, exploratory activity and barbiturate-sleeping time, using appropriate standard methods in mice. The extract exhibited dose-dependent CNS depressant activity.

摘要

将山芝麻的种子阴干、磨粉后，用乙醇通过索氏提取器进行提取。在减压条件下去除乙醇，干燥后得到粗提取物。采用适当的标准方法，在小鼠身上评估该提取物对行为变化、探索活动和巴比妥类睡眠时间的影响。该提取物表现出剂量依赖性的中枢神经系统抑制活性。

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