曲唑酮和间氯苯哌嗪（mCPP）对小鼠的镇痛作用：与吗啡的相互作用。

Antinociceptive effects of trazodone and m-chlorophenylpiperazine (mCPP) in mice: interaction with morphine.

Valeri P, Pimpinella G, Morrone L A, Romanelli L

Institute of Pharmacology and Pharmacognosy, University of Rome La Sapienza, Italy.

Gen Pharmacol. 1991;22(1):127-31. doi: 10.1016/0306-3623(91)90322-w.

Abstract

The antidepressant trazodone and its main metabolite m-chlorophenylpiperazine (mCPP) were investigated for their analgesic properties and their sensitivity to a threshold dose of morphine in acetic acid abdominal constriction and hot plate tests. 2. The drugs elicited hypoalgesic effects at about the same doses in the two analgesic assays. 3. Naloxone (2 mg/kg i.p.) prevented the hypoalgesia of trazodone but not of mCPP in the hot plate test. The opiate antagonist did not affect the responses of both drugs to the writhing test. 4. Subanalgesic doses of the two drugs increased the sensitivity to morphine in both assays. The results further support the suggested role played by opioid and 5-HT systems on depression.

摘要

对抗抑郁药曲唑酮及其主要代谢产物间氯苯哌嗪（mCPP）在醋酸诱发的腹部收缩试验和热板试验中的镇痛特性及其对阈剂量吗啡的敏感性进行了研究。2. 在两种镇痛试验中，这两种药物在大致相同的剂量下产生了镇痛作用。3. 在热板试验中，纳洛酮（2毫克/千克腹腔注射）可预防曲唑酮的镇痛作用，但不能预防mCPP的镇痛作用。阿片拮抗剂不影响两种药物对扭体试验的反应。4. 在两种试验中，低于镇痛剂量的这两种药物均可提高对吗啡的敏感性。这些结果进一步支持了阿片系统和5-羟色胺系统在抑郁症中所起的作用。