角蝰蛇毒的血流动力学效应。

The haemodynamic effect of Bitis nasicornis (rhinoceros horned viper) venom.

Alloatti G, Gattullo D, Dalla Valle R, Marsh N A, Pagliaro P, Vono P

Dipartimento di Biologia Animale, Università di Torino, Italy.

Gen Pharmacol. 1991;22(1):203-6. doi: 10.1016/0306-3623(91)90335-4.

Abstract

Intravenous venom (0.0625 mg/kg) in the dog caused an immediate increase in coronary blood flow due to a fall in coronary vascular resistance (CVR). 2. Subsequently, total peripheral resistance (TPR) fell causing a significant reduction in aortic blood pressure (ABP). 3. CVR and TPR returned to normal after 20 min but ABP did not recover completely. 4. The failure of ABP to recover was due to decreased stroke volume and cardiac output (CO). 5. Animals died after four doubling doses of venom following irreversible reductions in CO, ABP and coronary flow.

摘要

给狗静脉注射毒液（0.0625毫克/千克），由于冠状动脉血管阻力（CVR）下降，冠状动脉血流量立即增加。2. 随后，总外周阻力（TPR）下降，导致主动脉血压（ABP）显著降低。3. 20分钟后，CVR和TPR恢复正常，但ABP未完全恢复。4. ABP未能恢复是由于每搏输出量和心输出量（CO）降低。5. 在毒液剂量四次加倍后，动物因CO、ABP和冠状动脉血流量不可逆地减少而死亡。