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Tumor suppression by the histone demethylase UTX.

作者信息

Tsai Miao-Chih, Wang Jordon K, Chang Howard Y

出版信息

Cell Cycle. 2010 Jun 1;9(11):2043-4. doi: 10.4161/cc.9.11.11845.

Abstract
摘要

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本文引用的文献

1
The histone demethylase UTX enables RB-dependent cell fate control.
Genes Dev. 2010 Feb 15;24(4):327-32. doi: 10.1101/gad.1882610. Epub 2010 Feb 1.
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Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.
Nature. 2010 Jan 21;463(7279):360-3. doi: 10.1038/nature08672. Epub 2010 Jan 6.
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Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS.
Genes Dev. 2009 May 15;23(10):1177-82. doi: 10.1101/gad.511109.
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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.
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Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation.
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Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.
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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells.
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