Tumor suppression by the histone demethylase UTX.
作者信息
Tsai Miao-Chih, Wang Jordon K, Chang Howard Y
出版信息
Cell Cycle. 2010 Jun 1;9(11):2043-4. doi: 10.4161/cc.9.11.11845.
Abstract
摘要
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本文引用的文献
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The histone demethylase UTX enables RB-dependent cell fate control.组蛋白去甲基化酶 UTX 能够实现 RB 依赖性细胞命运控制。
Genes Dev. 2010 Feb 15;24(4):327-32. doi: 10.1101/gad.1882610. Epub 2010 Feb 1.
2
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.生发中心来源的滤泡性和弥漫性大 B 细胞淋巴瘤中 EZH2（Tyr641）改变的体细胞突变。
Nat Genet. 2010 Feb;42(2):181-5. doi: 10.1038/ng.518. Epub 2010 Jan 17.
3
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.系统测序肾细胞癌揭示组蛋白修饰基因失活。
Nature. 2010 Jan 21;463(7279):360-3. doi: 10.1038/nature08672. Epub 2010 Jan 6.
4
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS.组蛋白去甲基化酶JMJD3通过致癌性RAS参与INK4a/ARF的表观遗传调控。
Genes Dev. 2009 May 15;23(10):1177-82. doi: 10.1101/gad.511109.
5
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence.H3K27me3去甲基化酶JMJD3有助于INK4A-ARF基因座在致癌基因和应激诱导的衰老反应中被激活。
Genes Dev. 2009 May 15;23(10):1171-6. doi: 10.1101/gad.510809.
6
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.人类癌症中组蛋白H3K27去甲基化酶基因UTX的体细胞突变。
Nat Genet. 2009 May;41(5):521-3. doi: 10.1038/ng.349. Epub 2009 Mar 29.
7
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation.组蛋白H3赖氨酸27三甲基化在癌症中导致基因沉默，且不依赖于启动子DNA甲基化。
Nat Genet. 2008 Jun;40(6):741-50. doi: 10.1038/ng.159. Epub 2008 May 18.
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Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.组蛋白H3赖氨酸27位点的去甲基化调控多梳蛋白招募及组蛋白H2A泛素化。
Science. 2007 Oct 19;318(5849):447-50. doi: 10.1126/science.1149042. Epub 2007 Aug 30.
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EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.EZH2位于pRB - E2F信号通路的下游，对细胞增殖至关重要且在癌症中呈扩增状态。
EMBO J. 2003 Oct 15;22(20):5323-35. doi: 10.1093/emboj/cdg542.
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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells.EZH2是侵袭性乳腺癌的一个标志物，并促进乳腺上皮细胞的肿瘤转化。
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