利用电子转移解离（ETD）、碰撞诱导解离（CID）和离子淌度-质谱（IM-MS）鉴定肽中的药物金属化位点。
Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS).
机构信息
Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL.
出版信息
Chem Commun (Camb). 2010 Aug 14;46(30):5458-60. doi: 10.1039/c0cc00358a. Epub 2010 May 27.
PMID:20505878
Abstract
Electron transfer dissociation (ETD) and collision induced dissociation (CID) have been used to locate the precise binding sites for platinum and ruthenium anticancer complexes on the peptide Substance P. We show that ETD combined with ion mobility-mass spectrometry significantly reduces mass spectral complexity and improves the S/N of the product-ions formed.
摘要
电子转移解离（ETD）和碰撞诱导解离（CID）已被用于确定铂和钌抗癌配合物在肽物质 P 上的精确结合位点。我们表明，ETD 与离子淌度-质谱联用可显著降低质谱复杂性并提高所形成产物离子的 S/N。
Zotero 插件