过表达过氧化氢酶在肾近端肾小管细胞中的益处。
Benefits of catalase overexpression in renal proximal tubular cells.
机构信息
Division of Nephrology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Okayama 701-0192 Japan.
出版信息
Kidney Int. 2010 Jun;77(12):1060-2. doi: 10.1038/ki.2010.94.
The intrarenal renin-angiotensin system and reactive oxygen species contribute to the progression of chronic kidney disease. Godin et al. applied transgenic methods to prove renoprotection by catalase. They show that all of the pathological effects of overexpression of angiotensinogen can be attributed to stimulation of hydrogen peroxide pathways. This indicates a protective role for catalase and underscores the importance of the intrarenal renin-angiotensin system in renal disease.
肾内肾素-血管紧张素系统和活性氧自由基促进慢性肾脏病的进展。Godin 等人应用转基因方法证明了过氧化氢酶的肾保护作用。他们表明血管紧张素原过表达的所有病理作用都可以归因于对过氧化氢途径的刺激。这表明过氧化氢酶具有保护作用，并强调了肾内肾素-血管紧张素系统在肾脏疾病中的重要性。
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