Drugs R D. 2010;10(1):47-54. doi: 10.2165/11537740-000000000-00000.
Dapagliflozin, a selective inhibitor of the sodium glucose co-transporter type 2 (SGLT2) is in development for type 2 diabetes mellitus with Bristol-Myers Squibb and AstraZeneca. It is currently undergoing phase III development worldwide with regulatory submissions expected in the second half of 2010. This review looks at the development history and scientific profile of this drug to date.
达格列净,一种选择性钠-葡萄糖共转运蛋白 2(SGLT2)抑制剂,正由百时美施贵宝和阿斯利康联合开发用于治疗 2 型糖尿病。目前该药正在全球范围内进行 III 期临床试验,预计于 2010 年下半年提交监管部门审批。本文旨在回顾该药的研发历程和科学特征。