[E-钙黏蛋白和p120连环蛋白在乳腺浸润性小叶癌和导管癌中的表达模式及其意义]

Li Lan, Bi Xiao-feng, Xu Xin, Liu Xiu-yun, Shen Gui-hua, Guo Lei, Yuan Yan-ling, Wang Fang, Wang Ming-rong, Yang Hong-ying

Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical college, Beijing 100021, China.

Zhonghua Zhong Liu Za Zhi. 2010 Apr;32(4):273-7.

OBJECTIVE

To determine how patients with infiltrating lobular carcinoma (ILC) differ from patients with the more common infiltrating ductal carcinoma (IDC), and observe the different expression patterns of E-cadherin and p120-catenin proteins in both ILCs and IDCs.

METHODS

The patients with ILC admitted to our hospital from Jan 1999 to Dec 2006 and patients with IDC from Jan 2000 to Dec 2000 were included in this study. All their pathological slides were reviewed, and their clinical data and treatment variables were analyzed retrospectively. Then the expression patterns of E-cadherin and p120-catenin proteins in both ILCs and IDCs were detected by immunohistochemistry on tissue microarray.

RESULTS

The 5-year overall survival was 81.7% for ILCs and 79.1% for IDCs (P = 0.055). The 5-year disease-free survival was 61.8% for ILCs and 83.7% for IDCs (P < 0.001). Cytoplasmic localization of p120-catenin and loss of E-cadherin expression were more common in ILCs than in IDCs. The complete losses of E-cadherin in ILCs and IDCs were 55.6% (20/36) and 20.4% (45/221, P < 0.001), respectively. The p120-catenin showed a diffuse cytoplasmic localization in 66.7% (24/36) of ILCs and 16.3% (36/221) of IDCs (P < 0.001). Interestingly, the cytoplasmic localization of p120-catenin was clearly associated with the absence of E-cadherin expression in ILCs (P = 0.002), cytoplasmic localization of p120-catenin and absence of E-cadherin expression were observed 55.6% (20/36) in ILCs compared with 4.1% (9/221) in IDCs (P < 0.001).

CONCLUSION

ILC has several specific biological and prognostic characteristics which are different in IDC. Different expression patterns of E-cadherin and p120-catenin proteins can be helpful to recognize ILC from IDC.

目的

确定浸润性小叶癌（ILC）患者与更常见的浸润性导管癌（IDC）患者有何不同，并观察ILC和IDC中E-钙黏蛋白和p120-连环蛋白的不同表达模式。

方法

纳入1999年1月至2006年12月我院收治的ILC患者以及2000年1月至2000年12月的IDC患者。回顾所有患者的病理切片，并对其临床资料和治疗变量进行回顾性分析。然后通过组织芯片免疫组化检测ILC和IDC中E-钙黏蛋白和p120-连环蛋白的表达模式。

结果

ILC的5年总生存率为81.7%，IDC为79.1%（P = 0.055）。ILC的5年无病生存率为61.8%，IDC为83.7%（P < 0.001）。p120-连环蛋白的细胞质定位和E-钙黏蛋白表达缺失在ILC中比在IDC中更常见。ILC和IDC中E-钙黏蛋白的完全缺失分别为55.6%（20/36）和20.4%（45/221，P < 0.001）。p120-连环蛋白在66.7%（24/36）的ILC和16.3%（36/221）的IDC中呈弥漫性细胞质定位（P < 0.001）。有趣的是，在ILC中p120-连环蛋白的细胞质定位与E-钙黏蛋白表达缺失明显相关（P = 0.002），在ILC中观察到55.6%（20/36）的p120-连环蛋白细胞质定位和E-钙黏蛋白表达缺失，而在IDC中为4.1%（9/221）（P < 0.001）。