Shh 在肿瘤中的非细胞自主信号转导：治疗靶点的挑战和机遇。
Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets.
机构信息
University of California Berkeley, Department of Molecular and Cell Biology, Berkeley, CA 94720-3204, USA.
出版信息
Expert Opin Ther Targets. 2010 Jul;14(7):693-702. doi: 10.1517/14728222.2010.497488.
IMPORTANCE OF THE FIELD
The Hedgehog (Hh) pathway is required during many developmental events; in adults the Hedgehog pathway is involved in the maintenance of several stem cell niches. It is therefore not surprising that aberrantly regulated Hh pathway activity can cause birth defects in the developing organism, as well as neoplastic disease later in life.
AREAS COVERED IN THIS REVIEW
As a consequence of the involvement in pathogenesis, the Hh pathway components are subject to an intense scrutiny as potential targets for therapeutic agents. We aim to provide an overview of the biology of the Hh proteins and the cellular response, in conjunction with potential therapeutic interventions.
WHAT THE READER WILL GAIN
Specifically, we focus on the recently discovered non-cell-autonomous Shh signaling used by tumors and the implications of this for the design of treatment strategies. This should provide the reader with up-to-date knowledge on the role of the Hh pathway in tumor progression and the options to treat these malignancies.
TAKE HOME MESSAGE
An important concept that we advocate in this review is the need to recognize the need to target both the stromal and the tumor compartment in malignancies that rely on paracrine Shh signaling.
重要性领域
刺猬（Hh）信号通路在许多发育事件中是必需的；在成人中，刺猬信号通路参与几个干细胞龛的维持。因此，异常调节的 Hh 信号通路活性会导致发育中的生物体出现出生缺陷，以及以后生活中的肿瘤性疾病，这并不奇怪。
本篇综述涵盖的领域
由于参与发病机制，Hh 信号通路成分作为治疗药物的潜在靶点受到了强烈关注。我们旨在概述 Hh 蛋白的生物学和细胞反应，以及潜在的治疗干预措施。
读者将获得什么
具体而言，我们专注于最近发现的肿瘤中使用的非细胞自主 Shh 信号，以及这对治疗策略设计的影响。这应该为读者提供有关 Hh 通路在肿瘤进展中的作用以及治疗这些恶性肿瘤的选择的最新知识。
重要信息
在本篇综述中，我们提倡的一个重要概念是需要认识到需要针对依赖旁分泌 Shh 信号的恶性肿瘤中的基质和肿瘤区室进行靶向治疗。
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