豚鼠模型中血清和玻璃体液地高辛浓度的比较动力学。第一部分：地高辛静脉给药。
Comparative kinetics of serum and vitreous humor digoxin concentrations in a guinea pig model. Part I: Intravenous administration of digoxin.
作者信息
Donnelly B, Balkon J, Bidanset J H, Belmonte A, Barletta M, Manning T
机构信息
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, New York 11439.
出版信息
J Anal Toxicol. 1991 Mar-Apr;15(2):60-2. doi: 10.1093/jat/15.2.60.
The pharmacokinetics of a single intravenous dose of digoxin in the guinea pig was investigated with emphasis on the penetration of digoxin into the vitreous humor. A controlled study was undertaken and data was collected which indicated that digoxin follows an open, two-compartment pharmacokinetic model with a terminal half-life of 318 minutes. The data indicated that the ratio of vitreous concentrations to serum concentrations were determined to be equal following an initial tissue distribution phase.
研究了豚鼠单次静脉注射地高辛的药代动力学，重点关注地高辛在玻璃体内的渗透情况。进行了一项对照研究并收集了数据，结果表明地高辛遵循开放的二室药代动力学模型，终末半衰期为318分钟。数据表明，在初始组织分布阶段后，玻璃体内浓度与血清浓度的比值被确定为相等。
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