Department of Biochemistry, Institute of Natural and Applied Sciences, Middle East Technical University, Ankara, Turkey.
Neurol Sci. 2010 Dec;31(6):727-34. doi: 10.1007/s10072-010-0330-5. Epub 2010 Jun 2.
Oxidative stress plays a major role in pathogenesis of atherosclerosis which is responsible for stroke. Glutathione S-transferases (GSTs) detoxify metabolites produced by oxidative stress within the cell and protect the cells against injury. This study aimed to investigate the association of polymorphisms in GSTT1, GSTM1 genes and GST activity with ischemic stroke risk. Patients had almost the same GST activity as that of controls. No significant differences were found between patients and controls in terms of GSTT1 null, GSTM1 null and GSTT1/GSTM1 double null genotype frequencies. Besides, both patients and controls with double GSTT1/GSTM1 null genotypes had the lowest serum GST activities. Compared to the present genotypes, GSTT1 null (OR = 4.888; P = 0.006) and GSTM1 null (OR = 2.383; P = 0.011) genotype groups contained relatively more hypertensive stroke patients. This study showed that GSTT1 and GSTM1 null genotypes, together with hypertension, may play a significant role in the pathogenesis of ischemic stroke.
氧化应激在动脉粥样硬化的发病机制中起主要作用，而动脉粥样硬化是导致中风的原因。谷胱甘肽 S-转移酶（GSTs）可清除细胞内氧化应激产生的代谢物，保护细胞免受损伤。本研究旨在探讨 GSTT1、GSTM1 基因多态性与 GST 活性与缺血性中风风险的关系。患者的 GST 活性与对照组几乎相同。在 GSTT1 缺失、GSTM1 缺失和 GSTT1/GSTM1 双缺失基因型频率方面，患者与对照组之间没有发现显著差异。此外，具有 GSTT1/GSTM1 双缺失基因型的患者和对照组的血清 GST 活性均最低。与现有基因型相比，GSTT1 缺失（OR=4.888；P=0.006）和 GSTM1 缺失（OR=2.383；P=0.011）基因型组中相对较多的高血压性中风患者。本研究表明，GSTT1 和 GSTM1 缺失基因型与高血压一起，可能在缺血性中风的发病机制中起重要作用。
