Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK.
Eur J Immunol. 2010 Aug;40(8):2200-10. doi: 10.1002/eji.201040433.
IL-10 regulates the balance of an immune response between pathogen clearance and immunopathology. We show here that Mycobacterium tuberculosis (Mtb) infection in the absence of IL-10 (IL-10(-/-) mice) results in reduced bacterial loads in the lung. This reduction was preceded by an accelerated and enhanced IFN-γ response in the lung, an increased influx of CD4(+) T cells into the lung, and enhanced production of chemokines and cytokines, including CXCL10 and IL-17, in both the lung and the serum. Neutralization of IL-17 affected neither the enhanced production of CXCL10 nor the accumulation of IFN-γ-producing T cells in the lungs, but led to reduced numbers of granulocytes in the lung and reduced bacterial loads in the spleens of Mtb-infected mice. This suggests that IL-17 may contribute to dissemination of Mtb.
IL-10 调节病原体清除和免疫病理学之间的免疫反应平衡。我们在这里表明，在缺乏 IL-10 的情况下，结核分枝杆菌（Mtb）感染（IL-10(-/-) 小鼠）会导致肺部细菌载量减少。这种减少之前，肺部的 IFN-γ 反应加速和增强，CD4(+) T 细胞涌入肺部，以及趋化因子和细胞因子（包括 CXCL10 和 IL-17）在肺部和血清中的产生增加。IL-17 的中和既不影响 CXCL10 的增强产生，也不影响 IFN-γ 产生 T 细胞在肺部的积累，但导致肺部粒细胞数量减少和 Mtb 感染小鼠脾脏中细菌载量减少。这表明 IL-17 可能有助于 Mtb 的传播。
