Obi Y
Second Department of Surgery, Yokohama City University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1991 Mar;92(3):293-302.
Local injection of BRM (OK-432 or Lentinan) around the cancer lesions via endoscope was performed on 66 gastric cancer patients preoperatively, and the regional lymph node lymphocytes in the surgical specimens were examined on T-cell subset, production of IL-2, and responsiveness to IL-2. The results were as follows: 1) In the metastatic lymph nodes, proportions of T-lymphocyte subsets, production of IL-2 and responsiveness to IL-2 did not change after local administration of OK-432 or Lentinan. 2) In the non-metastatic lymph nodes, percentage of CD4+4B4+ cells were significantly increased and production of IL-2 was markedly augmented after local injection of OK-432. On the other hand, percentage of CD8+CD11- cells were significantly increased and production of IL-2 was markedly enhanced after the local injection of Lentinan. These data suggested that the antitumor response of the non-metastatic lymph node lymphocytes was augmented after the local injection of OK-432 or Lentinan.
对66例胃癌患者在术前通过内镜在癌灶周围局部注射生物反应调节剂（OK-432或香菇多糖），并对手术标本中的区域淋巴结淋巴细胞进行T细胞亚群、白细胞介素-2（IL-2）产生及对IL-2反应性的检测。结果如下：1）在转移淋巴结中，局部给予OK-432或香菇多糖后，T淋巴细胞亚群比例、IL-2产生及对IL-2反应性均未改变。2）在非转移淋巴结中，局部注射OK-432后，CD4+4B4+细胞百分比显著增加，IL-2产生明显增强。另一方面，局部注射香菇多糖后，CD8+CD11-细胞百分比显著增加，IL-2产生明显增强。这些数据表明，局部注射OK-432或香菇多糖后，非转移淋巴结淋巴细胞的抗肿瘤反应增强。
