来自阿诺特二歧茎草的桉烷型倍半萜内酯及其甲酯衍生物。

Eudesmanolides and methyl ester derivatives from Dimerostemma arnottii.

作者信息

Ambrosio Sérgio Ricardo, Stefani Ricardo, Heleno Vladimir Constantino Gomes, de Menezes Márcio Antônio, Ferreira Antonio Gilberto, Barboni Paulo Gustavo, Nascimento Dantas, Magenta Mara Angelina Galvão, Da Costa Fernando Batista

机构信息

Nutcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, 14404-600, Franca, SP, Brazil.

出版信息

Nat Prod Commun. 2010 May;5(5):669-74.

PMID:20521528

Abstract

The phytochemical investigation of Dimerostemma arnottii (Asteraceae) afforded, in addition to a known eudesmanolide, two unusual eudesmane methyl ester derivatives and a new eudesmanolide. Structural elucidation of the compounds was based on their 1D and 2D NMR spectroscopic as well as HR-ESI-MS data. There is a remarkable similarity between the structures of the eudesmanes from D. arnottii and those previously encountered in other Dimerostemma species, which is in agreement with the results of a previous phylogenetic study based on molecular data. The chemotaxonomic relevance of the isolated compounds is briefly discussed.

摘要

对阿诺特二歧茎（菊科）进行的植物化学研究，除了得到一种已知的桉叶烷型倍半萜内酯外，还获得了两种不寻常的桉叶烷甲酯衍生物和一种新的桉叶烷型倍半萜内酯。这些化合物的结构解析基于其一维及二维核磁共振光谱数据以及高分辨电喷雾电离质谱数据。阿诺特二歧茎中的桉叶烷结构与之前在其他二歧茎物种中发现的结构存在显著相似性，这与之前基于分子数据的系统发育研究结果一致。本文还简要讨论了所分离化合物的化学分类学意义。