Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
Psychophysiology. 2011 Jan;48(1):23-30. doi: 10.1111/j.1469-8986.2010.01038.x.
We recorded cortical activity in response to the onset, offset, and frequency change of a pure tone using magnetencephalograms (MEGs) to clarify the physiological significance of N1m relating to the detection of changes. Four interstimulus intervals (ISIs) (0.5, 1.5, 3, and 6 s) were used for each of the three auditory events. Results showed that (i) all three auditory events elicited N1m with a similar topography and similar temporal profile, (ii) the source of N1m was located in the superior temporal gyrus (STG) for all events under all ISI conditions, (iii) the amplitude of the STG activity as a function of the duration of the steady state preceding the change was similar among the three events, and (iv) there was a significant positive correlation in amplitude between on-N1m and off-N1m and between on-N1m and change-N1m. These results suggested that N1m for the three events has a similar physiological significance relating to the detection of changes.
我们使用脑磁图（MEG）记录了纯音起始、结束和频率变化时的皮层活动，以阐明与变化检测相关的 N1m 的生理意义。三个听觉事件的每个事件都使用了四个刺激间间隔（ISI）（0.5、1.5、3 和 6 秒）。结果表明：（i）所有三个听觉事件都诱发出具有相似拓扑和相似时间特征的 N1m；（ii）在所有 ISI 条件下，N1m 的源位于上颞叶（STG）；（iii）在三个事件中，在变化之前的稳态持续时间的函数中，STG 活动的幅度相似；（iv）在幅度上，on-N1m 和 off-N1m 之间以及 on-N1m 和 change-N1m 之间存在显著的正相关。这些结果表明，三个事件的 N1m 具有与变化检测相关的相似的生理意义。
