取代的N-[4(5-甲基/苯基-1,3,4-恶二唑-2-基)-3,6-二氢吡啶-1(2H)-基]苯甲酰胺/苯磺酰胺作为抗炎和抗癌剂的合成
Synthesis of Substituted N-[4(5-Methyl/phenyl-1,3,4-oxadiazol-2-yl)-3,6-dihydropyridin-1(2H)-yl]benzamide/benzene Sulfonamides as Anti-Inflammatory and Anti-Cancer Agents.
作者信息
Gangapuram Madhavi, Redda Kinfe K
机构信息
College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida 32307.
出版信息
J Heterocycl Chem. 2009 May 1;46(2):309-316. doi: 10.1002/jhet.62.
Abstract
Fourteen novel substituted N-[4(5-methyl/phenyl-1,3,4-oxadiazol-2-yl)-3,6-dihydropyridin-1(2H)-y1] benzamide/benzene sulfonamides (11a-n) were synthesized in fair to good yields via sodium borohydride reduction of the corresponding substituted N-(benzoylimino)-4-(5-methyl/5-phenyl-1,3,4-oxadiazol-2yl) pyridinium ylide (10a-n) in absolute ethanol.
摘要
通过在无水乙醇中用硼氢化钠还原相应的取代N-(苯甲酰基亚氨基)-4-(5-甲基/5-苯基-1,3,4-恶二唑-2-基)吡啶叶立德(10a-n)，以中等至良好的产率合成了14种新型取代的N-[4-(5-甲基/苯基-1,3,4-恶二唑-2-基)-3,6-二氢吡啶-1(2H)-基]苯甲酰胺/苯磺酰胺(11a-n)。
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