IDH1 R132H mutation is a rare event in myeloproliferative neoplasms as determined by a mutation specific antibody.
作者信息
Andrulis Mindaugas, Capper David, Meyer Jochen, Penzel Roland, Hartmann Christian, Zentgraf Hanswalter, von Deimling Andreas
出版信息
Haematologica. 2010 Oct;95(10):1797-8. doi: 10.3324/haematol.2010.024430. Epub 2010 Jun 9.
Abstract
摘要
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1
IDH1 R132H mutation is a rare event in myeloproliferative neoplasms as determined by a mutation specific antibody.通过一种突变特异性抗体检测发现，异柠檬酸脱氢酶1（IDH1）R132H突变在骨髓增殖性肿瘤中是一种罕见事件。
Haematologica. 2010 Oct;95(10):1797-8. doi: 10.3324/haematol.2010.024430. Epub 2010 Jun 9.
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本文引用的文献
1
Detection of isocitrate dehydrogenase 1 mutation R132H in myelodysplastic syndrome by mutation-specific antibody and direct sequencing.应用突变特异性抗体和直接测序检测骨髓增生异常综合征中异柠檬酸脱氢酶 1 突变 R132H。
Leuk Res. 2010 Aug;34(8):1091-3. doi: 10.1016/j.leukres.2010.02.014. Epub 2010 Mar 12.
2
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.白血病相关 IDH1 和 IDH2 突变的共同特征是一种新的酶活性，可将α-酮戊二酸转化为 2-羟基戊二酸。
Cancer Cell. 2010 Mar 16;17(3):225-34. doi: 10.1016/j.ccr.2010.01.020. Epub 2010 Feb 18.
3
Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms.骨髓增殖性肿瘤白血病转化过程中IDH1和IDH2的体细胞突变
N Engl J Med. 2010 Jan 28;362(4):369-70. doi: 10.1056/NEJMc0910063.
4
Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation.携带异柠檬酸脱氢酶 1 突变的成人急性髓细胞白血病具有独特的临床和生物学特征。
Blood. 2010 Apr 8;115(14):2749-54. doi: 10.1182/blood-2009-11-253070. Epub 2010 Jan 22.
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Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias.转化事件的遗传分析，这些事件将慢性骨髓增殖性肿瘤转化为白血病。
Cancer Res. 2010 Jan 15;70(2):447-52. doi: 10.1158/0008-5472.CAN-09-3783. Epub 2010 Jan 12.
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Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm.两种 JAK2 突变阳性骨髓增殖性肿瘤向白血病转化的途径。
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.癌症相关的 IDH1 突变会产生 2-羟基戊二酸。
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8
Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors.脑肿瘤中 R132H 突变特异性 IDH1 抗体结合的特征。
Brain Pathol. 2010 Jan;20(1):245-54. doi: 10.1111/j.1750-3639.2009.00352.x. Epub 2009 Oct 27.
9
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.IDH1和IDH2突变的类型及频率与星形胶质细胞和少突胶质细胞分化及年龄相关：一项对1010例弥漫性胶质瘤的研究
Acta Neuropathol. 2009 Oct;118(4):469-74. doi: 10.1007/s00401-009-0561-9. Epub 2009 Jun 25.
10
Mutation in TET2 in myeloid cancers.髓系癌症中TET2基因的突变。
N Engl J Med. 2009 May 28;360(22):2289-301. doi: 10.1056/NEJMoa0810069.
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