Labudda Kirsten, von Rothkirch Nadine, Pawlikowski Mirko, Laier Christian, Brand Matthias
Department of Physiological Psychology, University of Bielefeld, Germany.
Cogn Behav Neurol. 2010 Jun;23(2):89-97. doi: 10.1097/WNN.0b013e3181d83aa4.
To investigate whether patients with alcohol-related Korsakoff syndrome (KR) have emotion-specific or general deficits in multicategoric classification performance.
Earlier studies have shown reduced performance in classifying stimuli according to their emotional valence in patients with KS. However, it is unclear whether such classification deficits are of emotion-specific nature or whether they can also occur when nonemotional classifications are demanded.
In this study, we examined 35 patients with alcoholic KS and 35 healthy participants with the Emotional Picture Task (EPT) to assess valence classification performance, the Semantic Classification Task (SCT) to assess nonemotional categorizations, and an extensive neuropsychologic test battery.
KS patients exhibited lower classification performance in both tasks compared with the healthy participants. EPT and SCT performance were related to each other. EPT and SCT performance correlated with general knowledge and EPT performance in addition with executive functions.
Our results indicate a common underlying mechanism of the patients' reductions in emotional and nonemotional classification performance. These deficits are most probably based on problems in retrieving object and category knowledge and, partially, on executive functioning.
探讨酒精相关性柯萨科夫综合征（KR）患者在多类别分类表现中是否存在特定情绪或一般性缺陷。
早期研究表明，KS患者根据刺激的情绪效价进行分类的表现有所下降。然而，尚不清楚这种分类缺陷是否具有特定情绪性质，或者在需要进行非情绪分类时是否也会出现。
在本研究中，我们使用情绪图片任务（EPT）评估效价分类表现、语义分类任务（SCT）评估非情绪分类，并使用一套广泛的神经心理学测试，对35例酒精性KS患者和35名健康参与者进行了检查。
与健康参与者相比，KS患者在两项任务中的分类表现均较低。EPT和SCT表现相互关联。EPT和SCT表现与一般知识相关，EPT表现还与执行功能相关。
我们的结果表明，患者在情绪和非情绪分类表现下降存在共同的潜在机制。这些缺陷很可能是基于提取物体和类别知识方面的问题，部分是基于执行功能。
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