Department of Medicine & Nephrology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.
Ren Fail. 2010 Jul;32(6):647-52. doi: 10.3109/0886022X.2010.486097.
Patients in all stages of chronic kidney disease (CKD) are considered in the "high-risk group" for development of cardiovascular disease (CVD). The study was undertaken in 60 adult patients of chronic renal failure. The patients were divided into three groups: Group I had subjects with CKD (stages 1 and 2); Group II had subjects with CKD (stages 3 and 4) on conservative therapy for 3 months; and Group III had subjects with CKD (stage 5) on regular hemodialysis for at least 3-4 weeks. Carotid sonography was done in all patients at the time of inclusion in the study. The patients in all the groups were then followed for 6 months and the relevant investigations were carried out, initially at the time of presentation, and then at third- and sixth-month interval. The patients were monitored for various renal parameters along with serum lipoprotein-A [Lp (A)]. The value of carotid intima media thickness (CA-IMT) was increased in group II and III as compared to group I. The calcification of carotids was higher in patients of group III. The maximum number of patients having plaques and stenosis in the carotids were seen in group III (50%), followed by group II (20%). Patients in group III had 5-10 times higher levels of Lp (A) as compared to patients in group I. The comparison of Lp (A) levels between group I and group II was also highly statistically significant.
所有慢性肾脏病（CKD）阶段的患者都被认为是心血管疾病（CVD）发展的“高危人群”。本研究纳入了 60 例慢性肾功能衰竭成年患者。患者被分为三组：I 组为 CKD（1 期和 2 期）患者；II 组为 CKD（3 期和 4 期）患者，接受保守治疗 3 个月；III 组为 CKD（5 期）患者，定期接受至少 3-4 周的常规血液透析。所有患者在纳入研究时均进行颈动脉超声检查。所有组的患者随后随访 6 个月，并进行相关检查，最初在就诊时进行，然后在第 3 个月和第 6 个月进行。监测患者的各种肾功能参数以及血清脂蛋白-A [Lp（A）]。与 I 组相比，II 组和 III 组的颈动脉内膜中层厚度（CA-IMT）增加。III 组患者的颈动脉钙化程度更高。III 组中颈动脉斑块和狭窄的患者最多（50%），其次是 II 组（20%）。III 组患者的 Lp（A）水平比 I 组患者高 5-10 倍。I 组和 II 组之间的 Lp（A）水平比较也具有统计学意义。
