调节性T细胞与移植耐受
T regulatory cells and transplantation tolerance.
作者信息
Gorantla Vijay S, Schneeberger Stefan, Brandacher Gerald, Sucher Robert, Zhang Dong, Lee W P Andrew, Zheng Xin Xiao
机构信息
Division of Plastic Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
出版信息
Transplant Rev (Orlando). 2010 Jul;24(3):147-59. doi: 10.1016/j.trre.2010.04.002. Epub 2010 Jun 11.
Abstract
Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the "Holy Grail" of transplantation. The recent identification and characterization of regulatory T cells has opened up exciting opportunities for tolerance induction, immunotherapy, and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance.
摘要
尽管成功的免疫抑制方案得以发展，短期移植物存活率也有了巨大提高，但慢性移植物丢失问题仍然是临床移植的祸根。诱导和维持移植耐受是移植领域的“圣杯”。调节性T细胞的最新鉴定和表征为移植中的耐受诱导、免疫治疗和免疫调节带来了令人兴奋的机遇。本综述重点关注对调节性T细胞的当前认识及其在移植耐受中的作用。
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