Psychological Sciences, University of Melbourne, Victoria, Australia.
Epilepsy Behav. 2010 Aug;18(4):431-6. doi: 10.1016/j.yebeh.2010.05.003. Epub 2010 Jun 11.
The relationship between amygdalar volume and anxiety after epilepsy surgery was explored. Participants comprised patients who underwent mesial temporal (n=26) or non-mesial temporal resections (n=16) and 41 neurologically normal controls. Anxiety was prospectively measured preoperatively and for the first 12 months postoperatively using criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Amygdalar volumetry was performed on preoperative and control T1-weighted MRI scans. Resection of an ipsilateral amygdala of normal volume, relative to controls, was associated with postoperative anxiety in patients with mesial temporal resections, regardless of seizure outcome [F(1, 22)=5.17, P<0.05]. There was no relationship between amygdalar volume and anxiety in patients with non-mesial temporal resections, or between contralateral amygdalar volume and anxiety in patients with mesial temporal resections (P>0.05 for all comparisons). In conclusion, resection or deafferentation of an amygdala with a volume within the normal range was associated with increased postoperative anxiety.
探讨了杏仁核体积与癫痫手术后焦虑之间的关系。参与者包括接受内侧颞叶（n=26）或非内侧颞叶切除术（n=16）的患者和 41 名神经正常的对照者。使用《精神障碍诊断与统计手册》第四版的标准，前瞻性地测量了术前和术后 12 个月的焦虑症。在术前和对照组的 T1 加权 MRI 扫描上进行了杏仁核体积测量。与对照组相比，内侧颞叶切除术后，即使癫痫发作得到控制，同侧杏仁核体积正常的患者也会出现术后焦虑[F(1, 22)=5.17, P<0.05]。在非内侧颞叶切除患者中，杏仁核体积与焦虑之间没有关系，在接受内侧颞叶切除术的患者中，杏仁核体积与焦虑之间也没有关系（所有比较的 P>0.05）。总之，体积在正常范围内的杏仁核切除或去传入与术后焦虑增加有关。
