精神分裂症患者的起始反射前脉冲抑制在短期喹硫平治疗下保持稳定。
Prepulse inhibition of the startle reflex in schizophrenia remains stable with short-term quetiapine.
机构信息
Department of Psychiatry, Hospital Clínico Universitario de Salamanca, Paseo de San Vicente, 58-182, 37007 Salamanca, Spain.
出版信息
Eur Psychiatry. 2011 Jul-Aug;26(5):271-5. doi: 10.1016/j.eurpsy.2010.03.002. Epub 2010 Jun 9.
PURPOSE
To study the short-term effect of treatment with quetiapine on prepulse inhibition (PPI) deficits of the startle reflex in schizophrenia patients.
SUBJECTS AND METHODS
Using PPI, we studied a group of 21 schizophrenia patients and 16 controls. Seventeen of the patients were re-tested with PPI after 21 days of treatment with quetiapine.
RESULTS
At baseline, an almost significant decrease in PPI was found in the patients as compared to the controls. PPI measurements did not change in the patients after 21 days of treatment with quetiapine, despite their clinical improvement.
CONCLUSION
Our results suggest that short-term quetiapine treatment may not modify PPI measures in schizophrenia patients.
目的
研究喹硫平治疗对精神分裂症患者惊跳反射前脉冲抑制（PPI）缺陷的短期影响。
受试者和方法
使用 PPI，我们研究了一组 21 名精神分裂症患者和 16 名对照者。其中 17 名患者在接受喹硫平治疗 21 天后再次进行 PPI 测试。
结果
在基线时，与对照组相比，患者的 PPI 明显下降。尽管患者的临床症状有所改善，但在接受喹硫平治疗 21 天后，他们的 PPI 测量值并未发生变化。
结论
我们的结果表明，短期喹硫平治疗可能不会改变精神分裂症患者的 PPI 测量值。
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