cDNA sequence of Xenopus laevis bone morphogenetic protein 2 (BMP-2).
作者信息
Plessow S, Köster M, Knöchel W
机构信息
Department of Biochemistry, University of Ulm, F.R.G.
出版信息
Biochim Biophys Acta. 1991 Jun 13;1089(2):280-2. doi: 10.1016/0167-4781(91)90026-i.
PMID:2054389
Abstract
Screening of a Xenopus laevis ovary cDNA library with an oligonucleotide derived from the activin A sequence led to the isolation of several clones belonging to the TGF-beta supergene family. One of these clones codes for the Xenopus bone morphogenetic protein 2 (BMP-2). The deduced protein contains 398 amino acids with a predicted Mr of 45,581. Within the C-terminal 114 amino acids constituting the mature, biologically active protein there are only four exchanges (three of them are conservative ones) as compared to the corresponding human sequence.
摘要
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