Tong Yin, Li Lu, Liu Hui, Qian Wen-bin
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 May;39(3):246-9. doi: 10.3785/j.issn.1008-9292.2010.03.006.
Autophagy is a process of bulk degradation of proteins and organelles in cytoplasm.Autophagy has many normal physiological functions in cellular catabolism; therefore is essential for cell homeostasis. In some circumstances autophagy can induces cell death, namely autophagic cell death. Recent studies have suggested that autophagy plays an important role in both normal tissue development and a variety of diseases, including cancer. Therefore, the strategy targeting autophagy pathway may represent a new way of cancer treatment.
自噬是细胞质中蛋白质和细胞器大量降解的过程。自噬在细胞分解代谢中具有许多正常的生理功能,因此对细胞内环境稳定至关重要。在某些情况下,自噬可诱导细胞死亡,即自噬性细胞死亡。最近的研究表明,自噬在正常组织发育和包括癌症在内的多种疾病中都发挥着重要作用。因此,针对自噬途径的策略可能代表一种新的癌症治疗方法。