氟化物和钙钠磷硅酸钠牙膏对预软化牙本质脱矿和再矿化的体外影响。

Effect of fluoride and of calcium sodium phosphosilicate toothpastes on pre-softened dentin demineralization and remineralization in vitro.

机构信息

Department of Preventive and Community Dentistry, University of Athens, Dental School, 2 Thivon St. 115 27, Athens, Greece.

出版信息

J Dent. 2010 Aug;38(8):671-7. doi: 10.1016/j.jdent.2010.05.010. Epub 2010 Jun 9.

DOI:10.1016/j.jdent.2010.05.010

PMID:20546825

Abstract

OBJECTIVES

The purpose of this in vitro study was to evaluate the effect of toothpastes containing sodium fluoride in different concentrations or a calcium sodium phosphosilicate system on pre-softened dentin demineralization and remineralization.

METHODS

During a ten day pH-cycling protocol, pre-softened bovine root dentin slabs were immersed twice daily, after the demineralization periods, for 2min, in the following toothpaste slurries: (a) non-fluoridated (control), (b) 7.5% calcium sodium phosphosilicate, (c) 1450 ppm F, (d) 2800 ppm F and (e) 5000 ppm F. Subsequently, the specimens were subjected to a 15-h acid resistance test. Surface microhardness was assessed initially and during the pH-cycling and the acid resistance test period. Repeated measurements in each group were analyzed through appropriate regression models for longitudinal data.

RESULTS

All fluoride groups, during pH cycling, showed significantly less microhardness loss (p < or = 0.010, p < or = 0.002, p < or = 0.002) and subsequently exhibited increased acid resistance (p < or = 0.010, p < or = 0.001, p < or = 0.001) compared to the control. The 5000 ppm and 2800 ppm F toothpastes, inhibited demineralization significantly more effectively than the 1450 ppm F (p < or = 0.001, p < or = 0.030) and the calcium sodium phosphosilicate toothpaste (p < or = 0.001), while no significant differences were found between the two high fluoride groups (p=0.130). The calcium sodium phosphosilicate toothpaste, during pH cycling showed a difference that approached statistical significance compared to control (p=0.079), but its acid resistance behavior was similar to control (p=0.610).

CONCLUSIONS

Under these experimental conditions, the high fluoride toothpastes promoted remineralization and inhibited demineralization more effectively, than the 1450 ppm F, the non-fluoridated (control) and the calcium sodium phosphosilicate toothpastes.

摘要

目的

本体外研究的目的是评估含有不同浓度氟化物的牙膏或硅酸钙钠系统对预软化牙本质脱矿和再矿化的影响。

方法

在为期 10 天的 pH 循环方案中，每天两次将预软化的牛根牙本质薄片在脱矿期间浸泡在以下牙膏糊剂中 2 分钟：（a）非氟化（对照），（b）7.5%硅酸钙钠，（c）1450ppmF，（d）2800ppmF 和（e）5000ppmF。随后，将标本进行 15 小时耐酸性测试。在初始阶段以及 pH 循环和耐酸性测试期间评估表面显微硬度。通过适当的纵向数据回归模型分析每组中的重复测量值。

结果

所有氟化物组在 pH 循环期间均表现出显著较少的显微硬度损失（p≤0.010，p≤0.002，p≤0.002），随后表现出耐酸性增加（p≤0.010，p≤0.001，p≤0.001）与对照相比。与 1450ppmF（p≤0.001，p≤0.030）和硅酸钙钠牙膏（p≤0.001）相比，5000ppm 和 2800ppmF 牙膏更有效地抑制脱矿作用，而这两种高氟化物组之间没有发现显著差异（p=0.130）。在 pH 循环期间，硅酸钙钠牙膏与对照相比表现出差异接近统计学意义（p=0.079），但其耐酸性行为与对照相似（p=0.610）。