含特定型别和保守 M 蛋白表位的 A 群链球菌疫苗的保护效力。
Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes.
机构信息
Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
出版信息
Vaccine. 2010 Jul 12;28(31):5017-22. doi: 10.1016/j.vaccine.2010.05.018. Epub 2010 May 21.
Abstract
The amino terminal region of group A streptococcal M proteins evokes type-specific immunity while the conserved C-repeat epitopes evoke cross-protective immunity against multiple serotypes. The present studies were undertaken to compare the protective efficacy of vaccines containing either type-specific (hexavalent vaccine) or conserved C-repeat (J14 vaccine) M protein epitopes and to determine if combination vaccines resulted in enhanced levels of protection. Our results indicated that the protective efficacy of the type-specific vaccine was significantly greater than that of J14 and that the addition of J14 to vaccine formulations did not enhance the level of protection achieved with type-specific formulations.
摘要
A 组链球菌 M 蛋白的氨基末端区域引发型特异性免疫，而保守的 C 重复表位引发针对多种血清型的交叉保护免疫。本研究旨在比较含有型特异性（六价疫苗）或保守 C 重复（J14 疫苗）M 蛋白表位的疫苗的保护效力，并确定联合疫苗是否会增强保护水平。我们的结果表明，型特异性疫苗的保护效力明显大于 J14 疫苗，并且向疫苗配方中添加 J14 并不能增强与型特异性配方所达到的保护水平。
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本文引用的文献
1
STUDIES ON THE BIOLOGY OF STREPTOCOCCUS : I. ANTIGENIC RELATIONSHIPS BETWEEN STRAINS OF STREPTOCOCCUS HAEMOLYTICUS.链球菌生物学研究：I. 溶血链球菌菌株之间的抗原关系。
J Exp Med. 1919 Sep 1;30(3):179-213. doi: 10.1084/jem.30.3.179.
2
Group A streptococcal vaccines: facts versus fantasy.A 组链球菌疫苗：事实与幻想。
Curr Opin Infect Dis. 2009 Dec;22(6):544-52. doi: 10.1097/QCO.0b013e328332bbfe.
3
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Lancet Infect Dis. 2009 Oct;9(10):611-6. doi: 10.1016/S1473-3099(09)70178-1.
4
emm and C-repeat region molecular typing of beta-hemolytic Streptococci in a tropical country: implications for vaccine development.热带国家中β-溶血性链球菌的emm和C重复区域分子分型：对疫苗开发的意义
J Clin Microbiol. 2009 Aug;47(8):2502-9. doi: 10.1128/JCM.00312-09. Epub 2009 Jun 10.
5
Seven-year surveillance of north american pediatric group a streptococcal pharyngitis isolates.北美儿童A组链球菌性咽炎分离株的七年监测
Clin Infect Dis. 2009 Jul 1;49(1):78-84. doi: 10.1086/599344.
6
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PLoS One. 2009;4(1):e4166. doi: 10.1371/journal.pone.0004166. Epub 2009 Jan 9.
7
Current status of group A streptococcal vaccine development.A组链球菌疫苗研发的现状
Adv Exp Med Biol. 2008;609:53-63. doi: 10.1007/978-0-387-73960-1_5.
8
The epidemiology of invasive group A streptococcal infection and potential vaccine implications: United States, 2000-2004.2000 - 2004年美国侵袭性A组链球菌感染的流行病学及潜在疫苗影响
Clin Infect Dis. 2007 Oct 1;45(7):853-62. doi: 10.1086/521264. Epub 2007 Aug 29.
9
Intranasal vaccination with a lipopeptide containing a conformationally constrained conserved minimal peptide, a universal T cell epitope, and a self-adjuvanting lipid protects mice from group A streptococcus challenge and reduces throat colonization.用含有构象受限的保守最小肽、通用T细胞表位和自佐剂脂质的脂肽进行鼻内接种，可保护小鼠免受A组链球菌攻击并减少咽喉定植。
J Infect Dis. 2006 Aug 1;194(3):325-30. doi: 10.1086/505146. Epub 2006 Jun 20.
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