Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Vaccine. 2010 Jul 12;28(31):5017-22. doi: 10.1016/j.vaccine.2010.05.018. Epub 2010 May 21.
The amino terminal region of group A streptococcal M proteins evokes type-specific immunity while the conserved C-repeat epitopes evoke cross-protective immunity against multiple serotypes. The present studies were undertaken to compare the protective efficacy of vaccines containing either type-specific (hexavalent vaccine) or conserved C-repeat (J14 vaccine) M protein epitopes and to determine if combination vaccines resulted in enhanced levels of protection. Our results indicated that the protective efficacy of the type-specific vaccine was significantly greater than that of J14 and that the addition of J14 to vaccine formulations did not enhance the level of protection achieved with type-specific formulations.
A 组链球菌 M 蛋白的氨基末端区域引发型特异性免疫，而保守的 C 重复表位引发针对多种血清型的交叉保护免疫。本研究旨在比较含有型特异性（六价疫苗）或保守 C 重复（J14 疫苗）M 蛋白表位的疫苗的保护效力，并确定联合疫苗是否会增强保护水平。我们的结果表明，型特异性疫苗的保护效力明显大于 J14 疫苗，并且向疫苗配方中添加 J14 并不能增强与型特异性配方所达到的保护水平。
