School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
Can J Cardiol. 2010 Jun-Jul;26(6):201-5. doi: 10.1016/s0828-282x(10)70400-1.
The minimal and optimal amount of physical activity associated with cardiovascular health benefits in young people is unknown.
To determine the dose-response relationship between moderate-to-vigorous physical activity (MVPA) with high-risk low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride values in youth.
The study sample consisted of 1235 adolescents (12 to 19 years of age) from the 20032004 and 20052006 cycles of the United States National Health and Nutrition Examination Survey. Objective measures of MVPA were obtained over seven days with accelerometers. LDL cholesterol, HDL cholesterol and triglycerides were measured from a fasting blood sample. High-risk values for these lipidslipoproteins were determined using age- and sex-specific thresholds. Logistic regression models were used to determine the dose-response relationships between MVPA and high-risk lipid levels.
ORs for high-risk HDL cholesterol and triglyceride values decreased in a curvilinear manner with increasing minutes of MVPA. Compared with no MVPA (0 min), the ORs for high-risk HDL cholesterol values at 15 min, 30 min and 60 min per day of MVPA were 0.29 (95% CI 0.13 to 0.67), 0.24 (95% CI 0.10 to 0.64) and 0.21 (95% CI 0.07 to 0.61), respectively. The corresponding ORs for high-risk triglyceride values were 0.40 (95% CI 0.18 to 0.76), 0.22 (95% CI 0.06 to 0.66) and 0.10 (95% CI 0.01 to 0.51). There was no discernible dose-response relationship between MVPA and LDL cholesterol.
Small amounts of MVPA were associated with a large reduction in the likelihood of having high-risk HDL cholesterol and triglyceride values in this representative sample of adolescents.
目前尚不清楚与年轻人心血管健康益处相关的最低和最佳体力活动量。
确定青少年进行中高强度体力活动（MVPA）与高风险低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇和甘油三酯值之间的剂量反应关系。
研究样本由来自美国国家健康和营养检查调查 2003-2004 年和 2005-2006 年周期的 1235 名青少年（12-19 岁）组成。使用加速度计在七天内对 MVPA 进行客观测量。从空腹血样中测量 LDL 胆固醇、HDL 胆固醇和甘油三酯。使用年龄和性别特异性阈值确定这些脂质/脂蛋白的高危值。使用逻辑回归模型确定 MVPA 与高危血脂水平之间的剂量反应关系。
随着 MVPA 分钟数的增加，高危 HDL 胆固醇和甘油三酯值的比值呈曲线下降。与没有 MVPA（0 分钟）相比，MVPA 每天 15 分钟、30 分钟和 60 分钟时，高危 HDL 胆固醇值的比值分别为 0.29（95%CI 0.13 至 0.67）、0.24（95%CI 0.10 至 0.64）和 0.21（95%CI 0.07 至 0.61）。高危甘油三酯值的相应比值分别为 0.40（95%CI 0.18 至 0.76）、0.22（95%CI 0.06 至 0.66）和 0.10（95%CI 0.01 至 0.51）。MVPA 与 LDL 胆固醇之间没有明显的剂量反应关系。
在这个有代表性的青少年样本中，少量的 MVPA 与降低高危 HDL 胆固醇和甘油三酯值的可能性有很大关系。
