哺乳动物受精过程中通过 CatSper 通道的钙信号转导。
Calcium signaling through CatSper channels in mammalian fertilization.
机构信息
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
出版信息
Physiology (Bethesda). 2010 Jun;25(3):165-75. doi: 10.1152/physiol.00049.2009.
The molecular mechanisms underlying Ca(2+) entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility. We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca(2+) entry through CatSper channels instead of acting on Ca(V) and CNG channels as previously thought.
由于对成熟精子细胞的直接记录，Ca(2+) 进入精子的分子机制现在已经更加明确。本文综述了精子特异性离子通道 CatSper 的功能。CatSper 在精子的超活化运动中具有明确的功能，是男性生育所必需的。我们提出，生理刺激，如透明带和环核苷酸，通过 CatSper 通道诱导 Ca(2+) 内流，而不是像以前认为的那样作用于 Ca(V)和 CNG 通道。
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