Center for Cellular Neuroscience and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA.
FEBS Lett. 2010 Jul 16;584(14):3085-8. doi: 10.1016/j.febslet.2010.05.042. Epub 2010 May 27.
Abnormal tau cleavage is prominent in the neurofibrillary degeneration characteristic of Alzheimer's disease (AD) and related tauopathies. We recently showed that cleaved human tau is secreted by specific mechanisms when overexpressed. Here we examined the effect of expressing N-terminal and full length tau constructs in transiently and stably transfected neuronal lines. We show that secreted tau exhibits a cleavage pattern similar to CSF-tau from human AD patients and that tau secretion is specifically inhibited by the presence of the exon 2 insert. These results suggest that tau secretion may play a hitherto unsuspected role in AD and related tauopathies.
异常的 tau 切割在阿尔茨海默病（AD）和相关的 tau 病的神经纤维变性特征中很明显。我们最近表明，当过度表达时，切割的人 tau 通过特定的机制被分泌。在这里，我们研究了在瞬时和稳定转染的神经元系中表达 N 端和全长 tau 构建体的效果。我们表明，分泌的 tau 表现出与来自 AD 患者的 CSF-tau 相似的切割模式，并且 tau 的分泌被外显子 2 插入的存在特异性抑制。这些结果表明，tau 的分泌可能在 AD 和相关的 tau 病中发挥了迄今为止未被怀疑的作用。
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