儿童视神经炎的临床特征和结局。

Childhood optic neuritis clinical features and outcome.

机构信息

Institute of Child Health, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH.

出版信息

Arch Dis Child. 2011 Sep;96(9):860-2. doi: 10.1136/adc.2009.175422. Epub 2010 Jun 16.

DOI:10.1136/adc.2009.175422

PMID:20554767

Abstract

AIM

To describe clinical features and outcome of a series of children with first-episode optic neuritis investigated in three paediatric neurology centres.

METHODS

Databases were searched to identify children (<16 years) with optic neuritis and life table analysis was used.

RESULTS

44 children (female/male ratio 1.8) median age 10.9 years were followed up for median 1 year. Optic neuritis was unilateral in 43%. Maximal visual deficit was severe (<6/60) in 77%, with full recovery in 70%. Cumulative probability of developing MS (11/44) or NMO (3/44) at 2 years was 0.45. Relapsing optic neuritis was a strong predictor for development of MS or NMO. A positive MRI (>1 brain T2 hyperintense lesion) was a strong predictor for development of MS.

DISCUSSION

Childhood optic neuritis is associated with severe visual deficit with good recovery. An initial abnormal MRI brain scan or relapsing optic neuritis should alert the clinician to MS or NMO diagnosis.

摘要

目的

描述在三个儿科神经病学中心研究的一系列首发视神经炎患儿的临床特征和结局。

方法

通过数据库搜索，确定患有视神经炎的儿童（<16 岁），并使用生命表分析。

结果

44 名患儿（女性/男性比例为 1.8），中位年龄为 10.9 岁，中位随访时间为 1 年。视神经炎单侧受累者占 43%。最大视力缺损严重（<6/60）者占 77%，70%患者完全恢复。2 年内发生 MS（11/44）或 NMO（3/44）的累积概率为 0.45。复发性视神经炎是发生 MS 或 NMO 的强烈预测因素。初始异常 MRI 脑扫描或复发性视神经炎应提示临床医生考虑 MS 或 NMO 诊断。