Medicine, University of Miami School of Medicine, 1120 NW 14th Street, Room 1116, Miami, FL 33136, USA.
J Cardiovasc Transl Res. 2008 Jun;1(2):166-70. doi: 10.1007/s12265-008-9034-0. Epub 2008 May 23.
Advances in genomic technologies have provided researchers with an unprecedented opportunity to identify genes that may contribute to the development of coronary heart disease. The power of these technologies lies in their ability to survey the entire genome in a nonbiased fashion to find genes and gene variants associated with coronary heart disease. This article reviews different genomic approaches for studying coronary heart disease and the clinical implications of using genetic information.
基因组技术的进步为研究人员提供了一个前所未有的机会,可以识别可能导致冠心病的基因。这些技术的强大之处在于它们能够以无偏倚的方式对整个基因组进行调查,以找到与冠心病相关的基因和基因变异。本文综述了用于研究冠心病的不同基因组方法,以及使用遗传信息的临床意义。