难治性抑郁症的当前疾病分类学：一场抗拒修订的争议。
Current nosology of treatment resistant depression: a controversy resistant to revision.
作者信息
Fornaro Michele, Giosuè Patricia
机构信息
Department of Neuroscience, Section of Psychiatry, University of Genova, Genoa, Italy.
出版信息
Clin Pract Epidemiol Ment Health. 2010 May 4;6:20-4. doi: 10.2174/1745017901006010020.
Abstract
Treatment-Resistant Depression (TRD) represents a source of ongoing clinical and nosological controversy and confusion. While no univocal consensus on its definition and specific correlation with major mood disorders has been reached to date, a progressively greater number of evidences tend to suggest a revision of current clinical nosology. Since a better assessment of TRD should be considered mandatory in order to achieve the most appropriate clinical management, this narrative review aims to briefly present current most accepted definitions of the phenomenon, speculating on its putative bipolar diathesis for some of the cases originally assessed as unipolar depression.
摘要
难治性抑郁症（TRD）一直是临床和疾病分类学上争议与困惑的根源。尽管迄今为止尚未就其定义以及与主要情绪障碍的具体关联达成明确共识，但越来越多的证据倾向于表明需要对当前临床疾病分类学进行修订。由于为了实现最恰当的临床管理，对TRD进行更好的评估应被视为必要，本叙述性综述旨在简要介绍目前该现象最被认可的定义，并推测部分最初被评估为单相抑郁症的病例可能存在双相素质。
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