脆性组氨酸三联体基因（FHIT）：现在疑问已经明确。
FHIT: doubts are clear now.
作者信息
Wali Anjilna
机构信息
Cell and Molecular Biology Laboratory, Department of Biotechnology, University of Pune, Pune, Maharashtra, India.
出版信息
ScientificWorldJournal. 2010 Jun 16;10:1142-51. doi: 10.1100/tsw.2010.110.
The fragile histidine triad (FHIT) gene is a bonafide tumor-suppressor gene present on the short arm of chromosome 3 and its loss of function has been evaluated in different types of cancers. Loss of heterozygosity at various sections of the FHIT gene and the methylation analysis of the promoter region showed that it is one of the important and preliminary genetic alterations in the cell, and its restoration in the cell line or nude mice suppresses tumorigenicity. Current research on the FHIT gene has depicted that Fhit interacts with different proteins through different pathways in the nucleus, mitochondria, and cytoplasm, directing the cell to apoptosis.
脆性组氨酸三联体（FHIT）基因是位于3号染色体短臂上的一个真正的肿瘤抑制基因，其功能丧失已在不同类型的癌症中得到评估。FHIT基因不同区段的杂合性缺失以及启动子区域的甲基化分析表明，它是细胞中重要的早期基因改变之一，在细胞系或裸鼠中恢复其功能可抑制肿瘤发生。目前对FHIT基因的研究表明，Fhit通过细胞核、线粒体和细胞质中的不同途径与不同蛋白质相互作用，引导细胞凋亡。
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