AbdulQawi Khaled, Youssef Ahmed, Metwally Mohamed A, Ragih Ibrahim, AbdulHamid Mohamed, Shaheen AbdulAziz
Department of Pediatrics, Benha University, 2 Saad Zaghloul st, Benha, PO Box:113, Qualyabia governorate, Egypt.
Croat Med J. 2010 Jun;51(3):219-28. doi: 10.3325/cmj.2010.51.219.
To estimate the hepatitis C virus (HCV) vertical transmission rate, the effect of potential risk factors, and the pattern of HCV antibody response and viremia in HCV-infected infants in Benha, Egypt.
A total of 1224 pregnant women who were treated at Benha University Hospital, Egypt, were included in the study. They completed a questionnaire about risk factors for HCV acquisition and suspected risk factors for mother-to-infant transmission and were tested for HCV antibody using a third-generation ELISA test. Women positive for HCV antibody were tested for HCV RNA by polymerase chain reaction. Peripheral blood of infants of positive HCV-RNA women was tested for HCV antibody and HCV-RNA at 1 and after 6 months of age.
Out of 1224 pregnant women, 105 (8.6%; 95% confidence interval, 7.05-10.17) were positive for HCV antibody. Only 83 (6.8%; 5.39-7.21) were positive for HCV-RNA. HCV infection was associated with older age (1.16; 1.1-1.2, P=0.001), blood transfusion (2.69; 1.2-6.0, P=0.016), and HCV infection of the husband (5.47; 1.4-21, P=0.014) or other household members (2.29; 1.2-4.6, P=0.019). Out of 53 infants tested at first month, 43 (81%; 71-92%) were positive for HCV antibody, but only 7 (13%; 4.1-22%) were positive for HCV-RNA. After 6 months, only 2 (3.8%; 0-8.95%) remained positive for HCV RNA.
The prevalence of HCV in pregnant women in Egypt is lower than previously reported and the potential risk factors associated with HCV infection suggest intra-familial transmission. The frequency of vertical transmission of HCV in Egypt is not substantially different from other countries and does not play a role in the high prevalence of HCV in Egypt.
评估埃及本哈地区丙型肝炎病毒(HCV)的垂直传播率、潜在风险因素的影响以及HCV感染婴儿的HCV抗体反应和病毒血症模式。
本研究纳入了在埃及本哈大学医院接受治疗的1224名孕妇。她们完成了一份关于HCV感染风险因素及母婴传播疑似风险因素的问卷,并采用第三代酶联免疫吸附试验(ELISA)检测HCV抗体。HCV抗体阳性的女性通过聚合酶链反应检测HCV RNA。HCV - RNA阳性女性的婴儿外周血在1月龄和6月龄时检测HCV抗体和HCV - RNA。
1224名孕妇中,105名(8.6%;95%置信区间,7.05 - 10.17)HCV抗体阳性。仅83名(6.8%;5.39 - 7.21)HCV - RNA阳性。HCV感染与年龄较大(1.16;1.1 - 1.2,P = 0.001)、输血(2.69;1.2 - 6.0,P = 0.016)以及丈夫(5.47;1.4 - 21,P = 0.014)或其他家庭成员(2.29;1.2 - 4.6,P = 0.019)的HCV感染有关。在1月龄检测的53名婴儿中,43名(81%;71 - 92%)HCV抗体阳性,但仅7名(13%;4.1 - 22%)HCV - RNA阳性。6个月后,仅2名(