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埃及孕妇丙型肝炎患病率及危险因素及其母婴传播的前瞻性研究。

Prospective study of prevalence and risk factors for hepatitis C in pregnant Egyptian women and its transmission to their infants.

作者信息

AbdulQawi Khaled, Youssef Ahmed, Metwally Mohamed A, Ragih Ibrahim, AbdulHamid Mohamed, Shaheen AbdulAziz

机构信息

Department of Pediatrics, Benha University, 2 Saad Zaghloul st, Benha, PO Box:113, Qualyabia governorate, Egypt.

出版信息

Croat Med J. 2010 Jun;51(3):219-28. doi: 10.3325/cmj.2010.51.219.

Abstract

AIM

To estimate the hepatitis C virus (HCV) vertical transmission rate, the effect of potential risk factors, and the pattern of HCV antibody response and viremia in HCV-infected infants in Benha, Egypt.

METHODS

A total of 1224 pregnant women who were treated at Benha University Hospital, Egypt, were included in the study. They completed a questionnaire about risk factors for HCV acquisition and suspected risk factors for mother-to-infant transmission and were tested for HCV antibody using a third-generation ELISA test. Women positive for HCV antibody were tested for HCV RNA by polymerase chain reaction. Peripheral blood of infants of positive HCV-RNA women was tested for HCV antibody and HCV-RNA at 1 and after 6 months of age.

RESULTS

Out of 1224 pregnant women, 105 (8.6%; 95% confidence interval, 7.05-10.17) were positive for HCV antibody. Only 83 (6.8%; 5.39-7.21) were positive for HCV-RNA. HCV infection was associated with older age (1.16; 1.1-1.2, P=0.001), blood transfusion (2.69; 1.2-6.0, P=0.016), and HCV infection of the husband (5.47; 1.4-21, P=0.014) or other household members (2.29; 1.2-4.6, P=0.019). Out of 53 infants tested at first month, 43 (81%; 71-92%) were positive for HCV antibody, but only 7 (13%; 4.1-22%) were positive for HCV-RNA. After 6 months, only 2 (3.8%; 0-8.95%) remained positive for HCV RNA.

CONCLUSIONS

The prevalence of HCV in pregnant women in Egypt is lower than previously reported and the potential risk factors associated with HCV infection suggest intra-familial transmission. The frequency of vertical transmission of HCV in Egypt is not substantially different from other countries and does not play a role in the high prevalence of HCV in Egypt.

摘要

目的

评估埃及本哈地区丙型肝炎病毒(HCV)的垂直传播率、潜在风险因素的影响以及HCV感染婴儿的HCV抗体反应和病毒血症模式。

方法

本研究纳入了在埃及本哈大学医院接受治疗的1224名孕妇。她们完成了一份关于HCV感染风险因素及母婴传播疑似风险因素的问卷,并采用第三代酶联免疫吸附试验(ELISA)检测HCV抗体。HCV抗体阳性的女性通过聚合酶链反应检测HCV RNA。HCV - RNA阳性女性的婴儿外周血在1月龄和6月龄时检测HCV抗体和HCV - RNA。

结果

1224名孕妇中,105名(8.6%;95%置信区间,7.05 - 10.17)HCV抗体阳性。仅83名(6.8%;5.39 - 7.21)HCV - RNA阳性。HCV感染与年龄较大(1.16;1.1 - 1.2,P = 0.001)、输血(2.69;1.2 - 6.0,P = 0.016)以及丈夫(5.47;1.4 - 21,P = 0.014)或其他家庭成员(2.29;1.2 - 4.6,P = 0.019)的HCV感染有关。在1月龄检测的53名婴儿中,43名(81%;71 - 92%)HCV抗体阳性,但仅7名(13%;4.1 - 22%)HCV - RNA阳性。6个月后,仅2名(

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