Estación Experimental 'La Mayora', Consejo Superior de Investigaciones Científicas, 29750 Algarrobo-Costa, Málaga, Spain.
Mol Plant Pathol. 2004 May 1;5(3):223-33. doi: 10.1111/j.1364-3703.2004.00223.x.
SUMMARY Recent work carried out to characterize recessive mutations which render experimental hosts non-permissive to viral infection (loss-of-susceptibility mutants) seems to be converging with new data on natural recessive resistance in crop species, and also with functional analyses of virus avirulence determinants. Perhaps the most well known examples are the studies that identified the eukaryotic translation initiation factors 4E(iso) (eIF(iso)4E) and 4E(eIF4E) as the host factors required for potyvirus multiplication within experimental and natural hosts, respectively, and the potyviral genome-linked protein (VPg) as the viral factor that directly interacts with eIF4E to promote potyvirus multiplication. The purpose of this paper is to review the available information on the characterization of loss-of-susceptibility mutants in experimental hosts, natural recessive resistances and virus avirulence factors, and also to comment on possible implications for the design of new sources of sustainable virus resistance.
最近开展的工作对导致实验宿主对病毒感染不敏感的隐性突变（易感性丧失突变体）进行了特征描述，这似乎与作物品种中自然隐性抗性的新数据以及病毒无毒决定因素的功能分析相吻合。也许最著名的例子是那些研究，分别确定了真核翻译起始因子 4E(iso)（eIF(iso)4E）和 4E(eIF4E) 是实验和自然宿主中马铃薯 Y 病毒繁殖所需的宿主因子，以及马铃薯 Y 病毒基因组连接蛋白 (VPg) 是与 eIF4E 直接相互作用以促进马铃薯 Y 病毒繁殖的病毒因子。本文的目的是综述实验宿主易感性丧失突变体、自然隐性抗性和病毒无毒因子的特征描述方面的现有信息，并对设计新的可持续病毒抗性来源的可能影响进行评论。
