Chemical Pathology Department, Southampton University Hospitals NHS Trust, Southampton, UK.
Nephrol Dial Transplant. 2010 Oct;25(10):3142-7. doi: 10.1093/ndt/gfq347. Epub 2010 Jun 21.
Medical treatment of obesity and lifestyle modification have limited effectiveness in treating it in morbidly obese individuals. Importantly, bariatric surgery is regarded as the only therapy that is effective in maintaining significant weight loss in morbidly obese individuals. Despite the fact that bariatric surgery-induced weight loss is associated with a significant decrease in morbidity and mortality and improvement in renal function, bariatric surgery has recently been shown to be associated with a significant risk of nephrolithiasis. The main risk factor for nephrolithiasis is increased excretion of urinary oxalate. In this review, we discuss the association between bariatric surgery, an increased risk of renal stone formation and oxalate nephropathy.
肥胖的医学治疗和生活方式改变在治疗病态肥胖患者方面效果有限。重要的是，减重手术被认为是唯一有效的治疗方法，可以维持病态肥胖患者的显著体重减轻。尽管减重手术引起的体重减轻与发病率和死亡率的显著降低以及肾功能的改善有关，但最近的研究表明，减重手术与肾结石形成的风险显著增加有关。肾结石形成的主要危险因素是尿草酸排泄增加。在这篇综述中，我们讨论了减重手术、肾结石形成风险增加和草酸肾病之间的关联。
