State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Radiology. 2010 Jul;256(1):270-9. doi: 10.1148/radiol.10091543.
To present an unenhanced four-dimensional time-resolved dynamic magnetic resonance (MR) angiography technique with true fast imaging with steady-state precession-based spin tagging with alternating radiofrequency (STAR), also called TrueSTAR.
This study received Institutional Review Board approval and was HIPAA compliant. Informed consent was obtained from all study subjects. In eight healthy volunteers, the spatial and temporal resolution of the TrueSTAR technique were optimized. In another six healthy volunteers, the contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR) of the TrueSTAR dynamic MR angiography images were compared with those acquired by using a standard Look-Locker echo-planar technique by using the Wilcoxon signed rank test. Finally, one patient with an arteriovenous malformation (AVM) was studied by using this technique.
The SNR and CNR of the TrueSTAR dynamic MR angiography images were 29% and 39% higher, respectively, compared with those acquired by using a standard Look-Locker echo-planar imaging sequence (both P = .028). In the AVM patient, TrueSTAR dynamic MR angiography delineated the dynamic course of labeled blood flowing through feeding arteries into the nidus and draining veins.
The results suggest that TrueSTAR is a promising unenhanced dynamic MR angiography technique for clinical evaluation of cerebrovascular disorders such as AVM, steno-occlusive disease, and aneurysm.
介绍一种无需对比剂的四维时间分辨动态磁共振（MR）血管成像技术，采用基于稳态进动的自旋标记交替射频（STAR），也称为 TrueSTAR。
本研究获得了机构审查委员会的批准，并符合 HIPAA 规定。所有研究对象均获得了知情同意。在 8 名健康志愿者中，优化了 TrueSTAR 技术的空间和时间分辨率。在另外 6 名健康志愿者中，通过使用 Wilcoxon 符号秩检验比较了 TrueSTAR 动态 MR 血管成像图像的对比噪声比（CNR）和信噪比（SNR）与使用标准 Look-Locker 回波平面技术获得的图像的 CNR 和 SNR。最后，对 1 例动静脉畸形（AVM）患者进行了该技术的研究。
与使用标准 Look-Locker 回波平面成像序列获得的图像相比，TrueSTAR 动态 MR 血管成像图像的 SNR 和 CNR 分别提高了 29%和 39%（均 P =.028）。在 AVM 患者中，TrueSTAR 动态 MR 血管成像描绘了通过供血动脉进入病灶和引流静脉的标记血流的动态过程。
结果表明，TrueSTAR 是一种很有前途的无需对比剂的动态 MR 血管成像技术，可用于评估脑血管疾病，如动静脉畸形、狭窄性闭塞性疾病和动脉瘤。
