I 型糖尿病诊断时的甲状腺功能。

Thyroid function at diagnosis of type I diabetes.

机构信息

Department of Endocrinology and Diabetes, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UK.

出版信息

Arch Dis Child. 2011 Aug;96(8):777-9. doi: 10.1136/adc.2009.168799. Epub 2010 Jun 24.

DOI:10.1136/adc.2009.168799

PMID:20576659

Abstract

BACKGROUND

National guidelines recommend that thyroid function is assessed at diagnosis of type I diabetes (TIDM) and annually thereafter. This paper reports an audit of thyroid surveillance in accordance with this guideline.

PATIENTS

110 patients (66 males), median age 11.3 (1.2-15.7) years at diagnosis of TIDM, were monitored for 2.3 (0.7-4.2) years.

RESULTS

21/110 (19.0%) patients had abnormal thyroid function at diagnosis of TIDM. Of these, 16 had normal thyroid function on reassessment after 45 (3-540) days. Abnormalities of thyroid function occurred more commonly in children with diabetic ketoacidosis (DKA) than those who did not have DKA (9/29, 31.0% vs 12/81, 14.8%, p<0.025). At the end of the observation period, five (4.5%) patients had minor abnormalities of thyroid function not requiring treatment and three (2.7%) were treated.

CONCLUSIONS

Transient abnormalities of thyroid function are common at diagnosis of TIDM, and therefore, thyroid hormones should not be measured at this time.

摘要

背景

国家指南建议在诊断 1 型糖尿病（TIDM）时以及此后每年评估甲状腺功能。本文报告了根据该指南进行的甲状腺监测审核。

患者

110 名患者（66 名男性），诊断为 TIDM 时的中位年龄为 11.3（1.2-15.7）岁，监测时间为 2.3（0.7-4.2）年。

结果

110 名患者中有 21 名（19.0%）在诊断 TIDM 时甲状腺功能异常。其中，16 名在 45（3-540）天后重新评估时甲状腺功能正常。患有糖尿病酮症酸中毒（DKA）的儿童比没有 DKA 的儿童更容易出现甲状腺功能异常（9/29，31.0%比 12/81，14.8%，p<0.025）。在观察期结束时，5 名（4.5%）患者有无需治疗的轻微甲状腺功能异常，3 名（2.7%）接受了治疗。