Hipk 家族在眼球大小、晶状体形成和视网膜形态发生中的作用。

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis.

机构信息

Department of Ophthalmology and Visual Science, Kumamoto University, Graduate School of Medical Sciences, Kumamoto, Japan.

出版信息

FEBS Lett. 2010 Jul 16;584(14):3233-8. doi: 10.1016/j.febslet.2010.06.020. Epub 2010 Jun 19.

DOI:10.1016/j.febslet.2010.06.020

PMID:20579985

Abstract

Members of the homeodomain-interacting protein kinase (HIPK) family are involved in various intracellular regulatory mechanisms. The present study focused on clarifying the functions of HIPK family members in ocular organization during late embryogenesis. HIPK1 and HIPK2 were expressed in the inner retina during late embryogenesis. Hipk1(+/-)Hipk2(-/-) mice had a greater frequency of small eyes with a lens deficiency and abnormally laminated and thickened retinas than did wild-type littermates. These data indicate that Hipk1 and Hipk2 are involved in regulation of eye size, lens formation and retinal lamination during late embryogenesis.

摘要

同源结构域相互作用蛋白激酶 (HIPK) 家族的成员参与各种细胞内调节机制。本研究旨在阐明 HIPK 家族成员在胚胎晚期眼部组织中的功能。HIPK1 和 HIPK2 在胚胎晚期表达于内视网膜。与野生型同窝仔相比，Hipk1(+/-)Hipk2(-/-) 小鼠小眼的发生频率更高，伴有晶状体缺失和视网膜分层异常及增厚。这些数据表明，Hipk1 和 Hipk2 参与了胚胎晚期眼球大小、晶状体形成和视网膜分层的调控。