米非司酮（RU486），一种纯抗孕激素药物，与长春碱联合用于治疗孕激素受体阳性的硬纤维瘤。

Mifepristone (RU486), a pure antiprogesterone drug, in combination with vinblastine for the treatment of progesterone receptor-positive desmoid tumor.

机构信息

Division of Surgery, Assaf Harofeh Medical Center, Zerifin, Israel.

出版信息

Tech Coloproctol. 2010 Sep;14(3):265-7. doi: 10.1007/s10151-010-0591-2. Epub 2010 Jun 29.

PMID:20585823

Abstract

We report the case of a patient who developed a desmoid tumor following total proctocolectomy and J-pouch reconstruction that was unresponsive to any medical treatment. Based on estrogen receptor alpha (ERalpha) and progesterone receptor (PR) evaluation (ERalpha-negative, but PR-positive), treatment with mifepristone, a pure antiprogesterone drug, was initiated, and partial tumor regression was achieved.

摘要

我们报告了一例患者，其在接受全直肠结肠切除和 J 袋重建术后发生了纤维瘤病，对任何治疗均无反应。基于雌激素受体α（ERα）和孕激素受体（PR）评估（ERα 阴性，但 PR 阳性），开始使用米非司酮（一种纯孕激素拮抗剂）进行治疗，部分肿瘤得到了消退。