Health Protection Agency, London Regional Epidemiology Unit, Holborn Gate, 330 High Holborn, London WC1 7VV, UK.
J Public Health (Oxf). 2011 Jun;33(2):175-81. doi: 10.1093/pubmed/fdq046. Epub 2010 Jun 29.
Childhood tuberculosis (TB) represents a sentinel event of recent transmission and is an indication of the effectiveness of prevention and control interventions. We analysed the trends in the epidemiology of TB in children in London aged 0-14 years between 1999 and 2006.
Data were extracted from the Enhanced TB Surveillance System.
Between 1999 and 2006, there were 1370 cases of TB in children. Incidence was higher in older children and in girls. The incidence rates in London Boroughs varied from 0.4/100,000 to 32.7/100,000. Between 1999 and 2006, Black-Africans comprised 49.2% of all TB cases in children, children from the Indian Subcontinent 21.8% and Whites 8.5%. The proportion of cases born in the UK averaged 52.4% during this period. Of non-UK-born children 79.3% were diagnosed with TB within 5 years of entry.
Ethnicity, country of birth and age are important risk factors for development of. With an overall TB incidence in London exceeding 40/100,000, universal BCG immunization of all neonates should be considered across all London boroughs.
儿童结核病（TB）是近期传播的一个重要事件，也是预防和控制干预措施有效性的一个指标。我们分析了 1999 年至 2006 年期间伦敦 0-14 岁儿童结核病的流行病学趋势。
数据从强化结核病监测系统中提取。
1999 年至 2006 年期间，共有 1370 例儿童结核病病例。年龄较大的儿童和女孩发病率较高。伦敦各行政区的发病率从 0.4/100,000 至 32.7/100,000 不等。1999 年至 2006 年期间，黑人占儿童所有结核病病例的 49.2%，来自印度次大陆的儿童占 21.8%，白人占 8.5%。在此期间，在英国出生的儿童病例比例平均为 52.4%。在非英国出生的儿童中，79.3%在入境后 5 年内被诊断患有结核病。
种族、出生地和年龄是发病的重要危险因素。伦敦的总体结核病发病率超过 40/100,000，应考虑在所有伦敦行政区对所有新生儿进行普遍卡介苗免疫接种。
