Morgan K S, Siu K K W, Paganin D M
School of Physics, Monash University, Victoria 3800, Australia.
Opt Express. 2010 May 10;18(10):9865-78. doi: 10.1364/OE.18.009865.
We examine the projection approximation in the context of propagation-based phase contrast imaging using hard x-rays. Specifically, we consider the case of a cylinder or a rounded edge, as a simple model for the edges of many biological samples. The Argand-plane signature of a propagation-based phase contrast fringe from the edge of a cylinder is studied, and the evolution of this signature with propagation. This, along with experimental images obtained using a synchrotron source, reveals how propagation within the scattering volume is not fully described in the projection approximation's ray-based approach. This means that phase contrast fringes are underestimated by the projection approximation at a short object-to-detector propagation distance, namely a distance comparable to the free-space propagation within the volume. This failure of the projection approximation may become non-negligible in the detailed study of small anatomical features deep within a large body. Nevertheless, the projection approximation matches the exact solution for a larger propagation distance typical of those used in biomedical phase contrast imaging.
我们在使用硬X射线的基于传播的相衬成像背景下研究投影近似。具体而言,我们考虑圆柱体或圆形边缘的情况,将其作为许多生物样本边缘的简单模型。研究了来自圆柱体边缘的基于传播的相衬条纹在阿冈平面上的特征,以及该特征随传播的演变。这与使用同步加速器源获得的实验图像一起,揭示了在投影近似的基于射线的方法中,散射体积内的传播是如何未得到充分描述的。这意味着在短的物体到探测器传播距离(即与体积内自由空间传播相当的距离)下,投影近似会低估相衬条纹。在对大物体内部深处的小解剖特征进行详细研究时,投影近似的这种失效可能变得不可忽略。然而,对于生物医学相衬成像中使用的典型较大传播距离,投影近似与精确解相匹配。