Fisheries and Oceans Canada, Science Branch, Special Projects, P.O. Box 5667, St. John's, Newfoundland, Canada A1C 5X1.
Mass Spectrom Rev. 2010 Jul-Aug;29(4):606-50. doi: 10.1002/mas.20258.
Mass spectrometric studies are now playing a leading role in the elucidation of lipopolysaccharide (LPS) structures through the characterization of antigenic polysaccharides, core oligosaccharides and lipid A components including LPS genetic modifications. The conventional MS and MS/MS analyses together with CID fragmentation provide additional structural information complementary to the previous analytical experiments, and thus contribute to an integrated strategy for the simultaneous characterization and correct sequencing of the carbohydrate moiety.
质谱研究在阐明脂多糖（LPS）结构方面发挥着主导作用，其方法是对具有抗原性的多糖、核心寡糖和类脂 A 成分（包括 LPS 遗传修饰）进行特征分析。常规 MS 和 MS/MS 分析以及 CID 断裂可提供与先前分析实验互补的附加结构信息，从而有助于实现对碳水化合物部分进行同时特征分析和正确测序的综合策略。
