Suppr超能文献

负载肿瘤 B 细胞的树突状细胞引发针对小鼠γ疱疹病毒 68 的广泛免疫,但不能预防长期潜伏。

Dendritic cells loaded with tumor B cells elicit broad immunity against murine gammaherpesvirus 68 but fail to prevent long-term latency.

机构信息

Center for Vaccines and Immunity, Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205, USA.

出版信息

J Virol. 2010 Sep;84(17):8975-9. doi: 10.1128/JVI.00571-10. Epub 2010 Jun 30.

Abstract

It is still unknown whether a noninfectious gammaherpesvirus vaccine is able to prevent or reduce virus persistence. This led us to use dendritic cells loaded with tumor B cells as a vaccine approach for the murine gammaherpesvirus 68 (gammaHV68) model of infection. Dendritic cells loaded with UV-irradiated latently infected tumor B cells induce broad, strong, and long-lasting immunity against gammaHV68. Dendritic cell vaccination prevents the enlargement of lymph nodes and severely limits acute infection and early latency but does not prevent gammaHV68 from establishing long-term latency. Our findings support the concept that attenuated viruses may be the best vaccine option for preventing gammaherpesvirus persistence.

摘要

目前尚不清楚非传染性γ疱疹病毒疫苗是否能够预防或减少病毒持续感染。这促使我们使用负载肿瘤 B 细胞的树突状细胞作为感染小鼠γ疱疹病毒 68(γHV68)模型的疫苗接种方法。负载经紫外线照射潜伏感染肿瘤 B 细胞的树突状细胞可诱导针对γHV68 的广泛、强烈和持久的免疫。树突状细胞疫苗接种可防止淋巴结肿大,并严重限制急性感染和早期潜伏,但不能防止 γHV68 建立长期潜伏。我们的研究结果支持这样的概念,即减毒病毒可能是预防γ疱疹病毒持续感染的最佳疫苗选择。

相似文献

2
An optimized CD8+ T-cell response controls productive and latent gammaherpesvirus infection.
J Virol. 2005 Feb;79(4):2573-83. doi: 10.1128/JVI.79.4.2573-2583.2005.
4
Latent antigen vaccination in a model gammaherpesvirus infection.
J Virol. 2001 Sep;75(17):8283-8. doi: 10.1128/jvi.75.17.8283-8288.2001.
5
LXR Alpha Restricts Gammaherpesvirus Reactivation from Latently Infected Peritoneal Cells.
J Virol. 2019 Mar 5;93(6). doi: 10.1128/JVI.02071-18. Print 2019 Mar 15.
6
An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection.
J Virol. 2004 Jul;78(13):6827-35. doi: 10.1128/JVI.78.13.6827-6835.2004.
7
Gamma interferon blocks gammaherpesvirus reactivation from latency in a cell type-specific manner.
J Virol. 2007 Jun;81(11):6134-40. doi: 10.1128/JVI.00108-07. Epub 2007 Mar 14.
8
Antibody to a lytic cycle viral protein decreases gammaherpesvirus latency in B-cell-deficient mice.
J Virol. 2002 Nov;76(22):11460-8. doi: 10.1128/jvi.76.22.11460-11468.2002.
9
Role of B-cell proliferation in the establishment of gammaherpesvirus latency.
J Virol. 2005 Aug;79(15):9480-91. doi: 10.1128/JVI.79.15.9480-9491.2005.

本文引用的文献

1
Induction of protective immunity against murine gammaherpesvirus 68 infection in the absence of viral latency.
J Virol. 2010 Mar;84(5):2453-65. doi: 10.1128/JVI.01543-09. Epub 2009 Dec 16.
2
Memory generation and maintenance of CD8+ T cell function during viral persistence.
J Immunol. 2007 Jul 1;179(1):141-53. doi: 10.4049/jimmunol.179.1.141.
3
DC-based cancer vaccines.
J Clin Invest. 2007 May;117(5):1195-203. doi: 10.1172/JCI31205.
4
Translating innate immunity into immunological memory: implications for vaccine development.
Cell. 2006 Feb 24;124(4):849-63. doi: 10.1016/j.cell.2006.02.019.
6
Immune regulation of viral infection and vice versa.
Immunol Res. 2005;32(1-3):293-315. doi: 10.1385/IR:32:1-3:293.
7
Active Epstein-Barr virus infection after allogeneic stem cell transplantation: re-infection or reactivation?
Transpl Infect Dis. 2005 Mar;7(1):4-10. doi: 10.1111/j.1399-3062.2005.00084.x.
8
Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination.
Nat Med. 2005 Jul;11(7):748-56. doi: 10.1038/nm1257. Epub 2005 Jun 12.
9
Dendritic cells as therapeutic vaccines against cancer.
Nat Rev Immunol. 2005 Apr;5(4):296-306. doi: 10.1038/nri1592.
10
Generation of a latency-deficient gammaherpesvirus that is protective against secondary infection.
J Virol. 2004 Sep;78(17):9215-23. doi: 10.1128/JVI.78.17.9215-9223.2004.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验