Department of Neurophysiology and Cellular Biophysics, University of Göttingen, 37073 Göttingen, Germany.
J Neurosci. 2010 Jun 30;30(26):8965-73. doi: 10.1523/JNEUROSCI.4030-09.2010.
Cannabinoids modulate the activity of many neuronal cells, among them sensory neurons in the olfactory epithelium. Here we show that the endocannabinoid 2-arachidonoyl-glycerol (2-AG) is synthesized in both olfactory receptor neurons and glia-like sustentacular cells in larval Xenopus laevis. Its production in the latter depends on the hunger state of the animal. The essential effect of 2-AG in olfactory receptor neurons is the control of odorant detection thresholds via cannabinoid CB(1) receptor activation. Hunger renders olfactory neurons more sensitive. Endocannabinoid modulation in the nose may therefore substantially influence food-seeking behavior.
大麻素调节许多神经元细胞的活动,其中包括嗅上皮中的感觉神经元。在这里,我们表明内源性大麻素 2-花生四烯酰甘油(2-AG)在幼虫非洲爪蟾的嗅觉受体神经元和胶质样支持细胞中均有合成。后者的产生取决于动物的饥饿状态。2-AG 在嗅觉受体神经元中的主要作用是通过大麻素 CB1 受体的激活来控制气味检测阈值。饥饿使嗅觉神经元更加敏感。因此,鼻腔中的内源性大麻素调节可能会极大地影响觅食行为。