正电子发射断层扫描（FDG-PET）联合 CT 或肿瘤标志物在肺癌诊断中的应用。

Usefulness of combined FDG-PET with CT or tumour markers in lung cancer diagnosis.

机构信息

University of Bonn, Department of Nuclear Medicine, Bonn, Germany.

出版信息

Anticancer Res. 2010 May;30(5):1741-5.

PMID:20592372

Abstract

BACKGROUND

The synergy between in vitro and in vivo imaging was investigated in this study.

PATIENTS AND METHODS

Comparison of fluorodeoxyglucose positron-emission tomography (FDG-PET) and computerised tomography (CT) included 62 patients (group 1), while that for comparison of FDG-PET and serum tumour markers included 26 patients (group 2).

RESULTS

In group 1, FDG-PET had positive and negative predictive values of 81% and 80% respectively, compared to 73.7% and 71.4% for CT, respectively. Combined imaging showed 100% sensitivity and 100% specificity. In group 2, FDG-PET and CEA were both positive in 42.9%, and only CEA was falsely negative in all other cases. FDG-PET and TPA were both positive in 47.6%, and in 52.4% only FDG-PET was positive. NSE and SCC had 100% specificity; their sensitivity was 38% and 25%, respectively.

CONCLUSION

FDG-PET diagnosis was improved by CT. Because the serum tumour markers were falsely negative in more than 50% and there were no falsely negative results for FDG-PET, combined imaging may allow reduction of cut-off values for conventional serum tumour markers.

摘要

背景

本研究旨在探讨体外与体内成像的协同作用。

患者与方法

62 例患者（第 1 组）进行了氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）与计算机断层扫描（CT）的比较，26 例患者（第 2 组）进行了 FDG-PET 与血清肿瘤标志物的比较。

结果

第 1 组中，FDG-PET 的阳性预测值和阴性预测值分别为 81%和 80%，而 CT 分别为 73.7%和 71.4%。联合成像显示出 100%的灵敏度和 100%的特异性。第 2 组中，CEA 和 FDG-PET 均为阳性的占 42.9%，而其他所有病例 CEA 均为假阴性。TPA 和 FDG-PET 均为阳性的占 47.6%，而 52.4%仅 FDG-PET 为阳性。NSE 和 SCC 的特异性均为 100%；其灵敏度分别为 38%和 25%。