雌激素受体（ER）、孕激素受体（PR）及人表皮生长因子受体2（Her-2/neu）在子宫内膜癌中的表达：一项临床病理研究

Expression of ER, PR, and Her-2/neu in endometrial cancer: a clinicopathological study.

作者信息

Srijaipracharoen Sunamchok, Tangjitgamol Siriwan, Tanvanich Sujitra, Manusirivithaya Sumonmal, Khunnarong Jakkapan, Thavaramara Thaovalai, Leelahakorn Surawute, Pataradool Kamol

机构信息

Department of Obstetrics and Gynecology, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Bangkok, Thailand.

出版信息

Asian Pac J Cancer Prev. 2010;11(1):215-20.

PMID:20593959

Abstract

OBJECTIVE

To determine any association between expression of estrogen receptor (ER), progesterone receptor (PR), and Her-2/neu and clinicopathological features, including survival, of endometrial carcinoma (EMC) patients.

METHODS

Samples of formalin-fixed, paraffin-embedded tissue of 108 patients with EMC treated at our institution between January 1994 and December 2007 were immunohistochemically studied.

RESULTS

ER, PR, and Her-2/neu expression were positive in 59.3%, 65.7% and 2.8% of cases, respectively. Positive ER expression was significantly associated with grade I-II tumor while PR expression was linked with endometrioid histology, grade I-II tumor, less myometrial invasion (MI) and negative lymph node involvement. Her-2/neu expression was significantly associated with deep MI, while positive ER and negative Her-2/neu expression in combination was significantly associated with longer disease-free and overall survival.

CONCLUSION

ER expression is a good prognostic factor while Her-2/neu expression appears to be a poor indicator for both disease-free and overall survival, while PR tended to show favorable influence for only disease-free survival of Thai EMCs.

摘要

目的

确定子宫内膜癌（EMC）患者雌激素受体（ER）、孕激素受体（PR）和Her-2/neu的表达与包括生存率在内的临床病理特征之间的任何关联。

方法

对1994年1月至2007年12月在本机构接受治疗的108例EMC患者的福尔马林固定、石蜡包埋组织样本进行免疫组织化学研究。

结果

ER、PR和Her-2/neu表达分别在59.3%、65.7%和2.8%的病例中呈阳性。ER阳性表达与I-II级肿瘤显著相关，而PR表达与子宫内膜样组织学、I-II级肿瘤、较少的肌层浸润（MI）和阴性淋巴结受累有关。Her-2/neu表达与深部MI显著相关，而ER阳性和Her-2/neu阴性表达相结合与更长的无病生存期和总生存期显著相关。